| 引用本文:马先，贺杰，马俊帅.丹红注射液结合抗菌药物对腹股沟疝术后血清MMP-2、MMP-9、TIMP-2、TIMP-1及应激指标作用机制研究[J].世界中医药,2019,(09):. |
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| 丹红注射液结合抗菌药物对腹股沟疝术后血清MMP-2、MMP-9、TIMP-2、TIMP-1及应激指标作用机制研究 |
| Study on the Mechanism of Danhong Injection Combined with Antimicrobial Agents on Serum MMP-2, MMP-9, TIMP-2, TIMP-1 and Stress Indexes after Inguinal Hernia Surgery |
| 投稿时间：2018-11-30 |
| DOI：10.3969/j.issn.1673-7202.2019.09.040 |
| 中文关键词: 丹红注射液 腹股沟疝 血清 应激指标 机制研究 炎性反应因子 抗菌药物 绞窄性疝 |
| English Keywords:Danhong Injection Inguinal hernia Serum Stress index Mechanism study Inflammatory factors Antimicrobial agents Strangulated hernia |
| 基金项目:河北卫生厅医学科学研究重点课题计划项目(161460603) |
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| 中文摘要: |
| 目的:研究丹红注射液结合抗菌药物对腹股沟疝术后血清MMP-2、MMP-9、TIMP-2、TIMP-1及应激指标作用。方法：回顾性分析选取的2015年1月至2017年11月河北北方学院附属第一医院收治的绞窄性疝患者152例作为研究对象，按照术后不同的用药方法分为观察组（n=75）和对照组（n=77）。在腹股沟疝手术后，对照组患者单纯给予静脉注射常规抗菌药物。观察组在对照组患者的基础上额外增加丹红注射液。记录2组包括皮质醇（Cor）、去甲肾上腺素（NE）、醛固酮（ALD）等应激指标的变化幅度，以及血清MMP-2、MMP-9、TIMP-2、TIMP-1的水平比较。结果：观察组术后应激指标Cor，NE，和ALD均显著优于对照组；观察组检测后血清MMP-2、MMP-9、TIMP-2、TIMP-1水平，与对照组患者比较，差异有统计学意义(P<0.05)；观察组检测后炎性反应因子水平IFN-γ、TNF-α、IL-2、IL-4、IL-6、IL-10水平，与对照组患者比较，差异有统计学意义(P<0.05)。结论：丹红注射液结合抗菌药物对腹股沟疝术后恢复疗效显著，比起单纯使用抗菌药物，血清MMP-2、MMP-9、TIMP-2、TIMP-1水平、应激指标与炎性反应因子均有明显优势，值得临床广泛应用。 |
| English Summary: |
| To study the effects of Danhong Injection combined with antimicrobial agents on serum MMP-2, MMP-9, TIMP-2, TIMP-1 and stress indexes after inguinal hernia surgery.Methods:From January 2015 to November 2017, 152 patients with strangulated hernia admitted in The First Affiliated Hospital of Hebei North University were analyzed retrospectively.According to different medications after the surgery, they were randomly divided into observation group(n=75)and control(n=77)group.After the inguinal hernia surgery, patients in the control group were given routine intravenously antibiotics.And patients in the observation group, we added Danhong Injection on the treatment basis of the control group.Changes of cortisol(Cor), norepinephrine(NE), aldosterone(ALD)and other stress indexes were recorded in the 2 groups, and changes of serum MMP-2, MMP-9, TIMP-2 and TIMP-1 levels were compared.Results:In the observation group, the stress indexes Cor, NE and ALD were significantly better than those in the control group.The serum levels of MMP-2, MMP-9, TIMP-2 and TIMP-1 in the observation group were statistically different compared to those in the control group(P<0.05).Conclusion:The efficacy of Danhong Injection combined with antimicrobial agents is remarkable for the postoperative recovery of inguinal hernia.When comparing to the use of antibiotics alone, the serum MMP-2, MMP-9, TIMP-2 and TIMP-1 levels, stress indexes and inflammatory factors are superior.It is worth of promoting in clinic. |
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