| 引用本文:滕林1，孙凤娟1，回雪颖2.萆薢渗湿汤联合哌拉西林钠他唑巴坦钠治疗下肢丹毒的疗效及对血清细胞因子的影响[J].世界中医药,2019,(09):. |
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| 萆薢渗湿汤联合哌拉西林钠他唑巴坦钠治疗下肢丹毒的疗效及对血清细胞因子的影响 |
| Efficacy of BiXie Dampness-Percolating Decoction Combined with Piperacillin Sodium and Tazobactam Sodium in Leg Erysipelas and Their Influence on Serum Cytokines |
| 投稿时间：2019-03-01 |
| DOI：10.3969/j.issn.1673-7202.2019.09.047 |
| 中文关键词: 下肢丹毒 萆薢渗湿汤 哌拉西林钠他唑巴坦钠 一氧化氮 炎性反应 |
| English Keywords:Leg erysipelas BiXie Dampness-Percolating Decoction Piperacillin Sodium and Tazobactam Sodium NO Inflammatory reaction |
| 基金项目:黑龙江省中医药科研项目(ZHY16-064) |
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| 中文摘要: |
| 目的:探讨萆薢渗湿汤联合哌拉西林钠他唑巴坦钠治疗下肢丹毒的疗效,检测其对血清指标的影响及治疗安全性。方法:选取2016年5月至2018年10月黑龙江中医药大学附属第二医院收治的下肢丹毒患者82例作为研究对象,按照随机数表法分为对照组和观察组,每组41例。对照组接受哌拉西林钠他唑巴坦钠治疗,观察组在哌拉西林钠他唑巴坦钠治疗基础上加入萆薢渗湿汤进行联合治疗,持续治疗2周。比较2组患者的治疗效果、症状体征积分值、血清学指标［一氧化氮(NO)、白细胞介素1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子α(TNF-α)］及药物不良反应发生率的差异。结果:治疗后,观察组患者的治疗有效率高于对照组患者;肤色、肿胀程度、肤温、自觉疼痛等症状体征积分值低于对照组患者;血清NO、IL-1β、IL-1β、IL-6、TNF-α的含量低于对照组患者(P<0.05)。治疗期间,2组患者皮疹瘙痒、恶心呕吐、便秘腹泻等不良反应发生率的差异无统计学意义(P>0.05)。结论:萆薢渗湿汤治疗下肢丹毒的效果卓著,且具有良好的用药安全性。 |
| English Summary: |
| To investigate the efficacy of Xueyushi Decoction combined with piperacillin sodium and tazobactam sodium in the treatment of erysipelas of lower extremities,and to detect its influence on serum indexes and treatment safety.Methods:From May 2016 to Oct 2018,82 patients with erysipelas of lower extremities were divided into control group and combination group by random number table.The control group received piperacillin sodium and tazobactam sodium,and the combination group received Xuoshi Decoction on the basis of piperacillin sodium and tazobactam sodium for 2 weeks.The therapeutic effect,symptom and sign integral value,serological indexes ［nitric oxide(NO),interleukin-1 beta(IL-1 beta),interleukin-6(IL-6),tumor necrosis factor-alpha(TNF-alpha)］ and the incidence of adverse drug reactions were compared between the two groups.Results:After treatment,the effective rate of treatment in the combined group was higher than that in the control group;the scores of symptoms and signs such as skin color,swelling degree,skin temperature and conscious pain were lower than those in the control group; the levels of serum NO,IL-1beta,IL-1beta,IL-6 and TNF-alpha were lower than those in the control group(P<0.05).During the treatment period,there was no significant difference in the incidence of adverse reactions such as rash pruritus,nausea and vomitin g、constipation and diarrhea between the two groups(P>0.05).Conclusion:Xuanxueshi Decoction is effective in treating erysipelas of lower limbs and has good medication safety. |
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