| 引用本文:韩景波.化痰开痹汤治疗冠心病合并心功能不全（痰浊闭阻证）的临床疗效观察[J].世界中医药,2019,(09):. |
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| 化痰开痹汤治疗冠心病合并心功能不全（痰浊闭阻证）的临床疗效观察 |
| Observation on Clinical Efficacy of Huatan Kaibi Decoction in Coronary Heart Disease with Cardiac Insufficiency(Turbid Phlegm Obstuction Syndrome) |
| 投稿时间：2018-07-10 |
| DOI：10.3969/j.issn.1673-7202.2019.09.048 |
| 中文关键词: 冠心病 慢性心功能不全 化痰开痹汤 心功能分级 左室射血分数 脑利钠肽 左心室收缩末期内径 左心室舒张末期内径 生命质量改善评分 |
| English Keywords:Coronary heart disease Chronic cardiac insufficiency Huatan Kaibi Decoction Cardiac functional grading Left ventricular ejection fraction Brain atriuretic peptide Left ventricular end-systolic dimension Left ventricular HYPERLINK "C:/Users/Administrator/AppData/Local/youdao/dict/Application/8.5.1.0/resultui/html/index.html" /l "/javascript: " end-diastolic dimension Quality of life improvement score |
| 基金项目:2013年广西卫生适宜技术研究与开发项目（S201307-04）；全国名老中医药专家传承工作室建设项目 |
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| 中文摘要: |
| 目的：探讨化痰开痹汤治疗冠心病合并心功能不全（痰浊闭阻证）的临床疗效。方法：选取2017年1月至2017年10月广西中医药大学第一附属医院收治的冠心病心功能Ⅱ~Ⅳ级的患者60例作者作为研究对象，采用随机数字表法随机分为对照组和观察组，每组30例，对照组患者给予西医常规治疗，观察组在对照组治疗的基础上加用化痰开痹汤治疗，比较2组治疗前后的心功能分级、脑利钠肽水平、左心室射血分数、左室收缩末期内径及左室舒张末期内径、生命质量改善评分的变化。结果：心功能分级总有效率观察组为90%，对照组为76.67%，2组比较无统计学意义；2组治疗后均能明显降低脑利钠肽水平，提高左室射血分数，降低左室收缩末期内径及左室舒张末期内径及降低生命质量改善评分，但观察组优于对照组，差异有统计学意义。结论：化痰开痹汤可以改善冠心病慢性心功能不全（痰浊闭阻证）患者的心功能状况，提高患者的生命质量，且安全可靠，值得进一步研究。 |
| English Summary: |
| To explore clinical efficacy of Huatan Kaibi Decoction in coronary heart disease(CHD）with cardiac insufficiency(turbid phlegm obstruction syndrome).Methods:A total of 60 CHD patients with cardiac function Ⅱ-Ⅳ grade admitted in the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine from January 2017 to October 2017 were selected as research objects，and they were randomly divided into control group and observation group，with 30 patients in each group.The control group was treated with routine western medicine.The observation group was treated with Huatan Kaibi Decoction on the treatment basis of the control group.Changes of cardiac functional grading，brain natriuretic peptide(BNP）level，left ventricular ejection fraction(LVEF)，left ventricular end-systolic dimension(LVSD)，left ventricular end-diastolic dimension(LVDD）and quality of life improvement score were compared between the 2 groups before and after the treatment.Results:From the aspect of cardiac functional grading，the total effective rate in the observation group was 90%，while that in the control group was 76.67%，with no statistical difference between the 2 groups.In the 2 groups after the treatment，the BNP level was significantly decreased，the LVEF was increased，and the LVSD，LVDD and quality of life improvement score were decreased.But those in the observation group were better than those in the control group，and the difference was statistically significant.Conclusion:Huatan Kaibi Decoction can improve the cardiac function in CHD patients with chronic cardiac insufficiency(turbid phlegm obstruction syndrome)，and improve patients' quality of life，with safety and reliability.So，it is worthy of further study. |
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