| 引用本文:郑明岳1,2，吴耀持2.委中穴对腰椎间盘突出症急性期的镇痛效应及对TNF-α、CD62P的影响[J].世界中医药,2019,(09):. |
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| 委中穴对腰椎间盘突出症急性期的镇痛效应及对TNF-α、CD62P的影响 |
| Analgesic Effect of Weizhong(BL 40)on Acute Stage of Lumbar Intervertebral Disc Herniation and Effect on TNF-α and CD62P |
| 投稿时间：2019-01-24 |
| DOI：10.3969/j.issn.1673-7202.2019.09.055 |
| 中文关键词: 委中穴 腰椎间盘突出症 急性期 疼痛视觉模拟评分 肿瘤坏死因子-α α颗粒膜糖蛋白 血液流变学 炎性反应因子 疗效 |
| English Keywords:Weizhong(BL 40) Lumbar intervertebral disc herniation Acute stage Pain visual analogue score Tumor necrosis factor-α A granular membrane glycoprotein Hemorheology Inflammatory factors Therapeutic effect |
| 基金项目:虹口区“国医强优”三年行动计划(2018-2020)项目(HGY-MZY-2018-07) |
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| 中文摘要: |
| 目的:探究委中穴对腰椎间盘突出症急性期镇痛效应及对肿瘤坏死因子-α(TNF-α)、α颗粒膜糖蛋白(CD62P)影响性。方法:选取2017年1月至2019年1月上海交通大学附属第六人民医院收治的腰椎间盘突出症急性期患者136例作为研究对象,按照就诊顺序编号随机分为对照组和观察组,每组68例。对照组常规西医治疗,观察组加用委中穴刺络拔罐,均治疗1周。观察2组患者治疗前、完成治疗后各评分、TNF-α、CD62P、P物质(SP)、白细胞介素-6(IL-6)、前列腺素E2(PGE2)腰椎功能、血液流变学变化并比较;完成治疗后进行疗效评价。结果:1)完成治疗后2组患者TNF-α、CD62P、SP、IL-6、PGE2较治疗前均显著下降(P<0.05),完成治疗后观察组以上指标均显著低于于对照组(P<0.05)。2)完成治疗后2组患者疼痛视觉模拟评分(VAS评分)、Oswestry功能障碍指数(ODI评分)较治疗前均显著下降,日本骨科协会评估治疗分数(JOA评分)显著升高(P<0.05),完成治疗后观察组VAS、ODI显著低于对照组,JOA显著高于对照组(P<0.05)。3)完成治疗后2组患者腰椎最大活动度、腰椎肌力正常百分比的前屈、后伸较治疗前均显著升高(P<0.05),完成治疗后观察组以上指标均显著高于对照组(P<0.05)。4)完成治疗后2组患者全血黏度、血浆黏度、红细胞压积、红细胞聚集指数、红细胞变形指数较治疗前均显著下降(P<0.05),完成治疗后观察组以上指标均显著低于对照组(P<0.05)。5)完成治疗后观察组治愈率、总有效率均显著高于对照组,比较差异有统计学意义(P<0.05)。结论:刺络拔罐委中穴能促进腰椎间盘突出症急性期血液循环,抑制炎性反应,改善疼痛,提高疗效。 |
| English Summary: |
| To explore the analgesic effect of Weizhong(BL 40)on acute lumbar disc herniation and its effect on tumor necrosis factor-α(TNF-α)and a granular membrane glycoprotein(CD62P).Methods:From January 2017 to January 2019,136 patients with acute lumbar disc herniation admitted in The Sixth People's Hospital affiliated to Shanghai Jiaotong University were randomly divided into a control group(68 cases)and an observation group(68 cases)according to treatment order.The control group was treated with routine western medicine,while the observation group was treated with Weizhong(BL 40)puncture and cupping for 1 week.The changes of scores,TNF-α,CD62P,substance P(SP),interleukin-6(IL-6),prostaglandin E2(PGE2)lumbar vertebral function and hemorheology before and after treatment were observed and compared between the 2 groups.The therapeutic effect was evaluated after treatment.Results:1)After treatment,TNF-α,CD62P,SP,IL-6 and PGE2 in the 2 groups were significantly lower than those before treatment(P<0.05),and the above indexes in the observation group were significantly lower than those in the control group(P<0.05).2)Pain visual analogue score(VAS)and oswestry dysfunction index(ODI)significantly decreased in both groups after treatment,and JOA score significantly increased(P<0.05).After treatment,VAS and ODI in the observation group were significantly lower than those in the control group,and JOA was significantly higher than those in the control group(P<0.05).3)The maximum range of motion of lumbar spine and the normal percentage of lumbar muscle strength in the 2 groups after treatment significantly higher than those before treatment(P<0.05),and the above indexes in the observation group were significantly higher than those in the control group after treatment(P<0.05).4)After treatment,the whole blood viscosity,plasma viscosity,hematocrit,erythrocyte aggregation index and erythrocyte deformability index of the 2 groups were significantly lower than those before the treatment(P<0.05),and the above indexes of the observation group were significantly lower than those of the control group(P<0.05).The cure rate and total effective rate of the observation group were significantly higher than those of the control group after the treatment,and the difference was statistically significant(P<0.05).Conclusion:Blood-letting puncture and cupping at Weizhong(BL 40)point can promote blood circulation,inhibit inflammatory reaction,improve pain and improve curative effect in acute stage of lumbar intervertebral disc herniation. |
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