世界中医药

目的：观察定眩止痛贴对阴虚火旺型老年高血压患者的治疗效果。方法：选取2016年7月至2017年6月陕西中医药大学附属医院收治的中医辨证为阴虚火旺型老年性高血压患者153例作为研究对象，随机分为对照组（n=76）和观察组（n=77）。对照组单独采用复方罗布麻片治疗，观察组采用定眩止痛贴配合复方罗布麻片治疗，观察治疗期间患者相关指标的变化以及临床疗效。结果：1)血糖及血脂变化：观察组治疗后FPG（4.57±0.42）mmol/L与2 hFBC（6.04±0.73）mmol/L，对照组治疗后FPG（6.53±0.68）mmol/L与2 hFBC（9.85±0.96）mmol/L。观察组治疗后HDL-C（1.84±0.36）mmol/L、TC（4.39±0.82）mmol/L、TG（1.14±0.47）mmol/L与LDL-C（1.86±0.28）mmol/L。对照组治疗后HDL-C（1.29±0.30）mmol/L、TC（5.88±1.17）mmol/L、TG（1.88±0.84）mmol/L与LDL-C（2.49±0.35）mmol/L。2)血流变学指标：经过治疗，2组患者血流变学指标均有所降低，其中观察组全血高切黏度（5.22±0.57）mPa·s、全血低切黏度（10.24±1.09）mPa·s、血浆比黏度（1.44±0.26）mPa·s、纤维蛋白原（3.03±0.26）g/L与对照组比较存在明显优势。3)中医阴虚火旺证候积分：观察组总积分从（15.41±0.36）下降至（3.31±0.22），对照组总积分从（15.29±0.43）下降至（6.79±0.25）。4)血压变化：观察组治疗后收缩压（121.44±4.14）mmHg、舒张压（81.26±3.18）mmHg、以及脉压（37.94±1.21）mmHg均有明显下降，收缩压昼夜节律（7.14±1.86）%与舒张压昼夜节律（9.46±2.88）%得到明显回升，指标改善明显优于对照组。结论：定眩止痛贴配合复方罗布麻片治疗阴虚火旺型老年高血压患者作用明显，促进血糖血脂水平恢复，降低血流变学指标，从而改善患者的血压症状。

English Summary:

To observe the efficacy of Dingxuan Zhitong Paste in treating patients with senile hypertension of yin deficiency resulting in effulgent fire syndrome.Methods:From July 2016 to June 2017，153 cases with senile hypertension of yin deficiency resulting in effulgent fire syndrome admitted in the Affiliated Hospital of Shaanxi University of Chinese Medicine were selected as research objects and analyzed retrospectively.According to different drug therapies，they were randomly divided into control group(n＝76）and observation group(n＝77).The observation group was treated with Dingxuan Zhitong Paste and Compound Kendir Leaves Tablets，while the control group was treated with the Compound Kendir Leaves Tablets alone.Changes of related indexes in the patients and clinical efficacy during the treatment were observed.Results:1）The changes of blood glucose and blood lipid：In the observation group after the treatment，FPG(4.57±0.42）mmol/L and 2 hFBC(6.04±0.73）mmol/L.In the control group after the treatment，FPG(6.53±0.68）mmol/L and 2 hFBC(9.85±0.96）mmol/L.In the observation group after the treatment，HDL-C(1.84±0.36）mmol/L，TC(4.39±0.82）mmol/L，TG(1.14±0.47）mmol/L and LDL-C(1.86±0.28）mmol/L.After the treatment in the control group，HDL-C(1.29±0.30）mmol/L，TC(5.88±1.17）mmol/L，TG(1.88±0.84）mmol/L and LDL-C(2.49±0.35）mmol/L. 2）Hemorheology：After the treatment，the hemorheological indexes of patients were decreased.The whole blood high shear viscosity(5.22±0.57）mPa·s，whole blood low shear viscosity(10.24±1.09）mPa·s，plasma specific viscosity(1.44±0.26）mPa·s and fibrinogen(3.03±0.26）g/L in the observation group were significantly superior to those in the control group. 3）Syndrome integral of yin deficiency resulting in effulgent fire in traditional Chinese medicine(TCM)：The total integral in the observation group was decreased from(15.41±0.36）to(3.31±0.22)，that in the control group was decreased from(15.29±0.43）to(6.79±0.25). 4）Blood pressure changes：In the observation group after the treatment，systolic pressure(121.44±4.14）mmHg，diastolic pressure(81.26±3.18）mmHg and pulse pressure(37.94±1.21）mmHg were significantly decreased.The circadian rhythm of systolic pressure(7.14±1.86)% and the circadian rhythm of diastolic pressure(9.46±2.88)% were increased significantly.The improvement of indexes was better than that in the control group.Conclusion:For the treatment in patients with senile hypertension of yin deficiency resulting in effulgent fire syndrome，Dingxuan Zhitong Paste combined with Compound Kendir Leaves Tablets has significant efficacy.It can promote recovery of blood glucose and blood lipid levels and decrease hemorheology indexes，thus improving blood pressure symptoms of the patients.

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