| 引用本文:迟艳艳.右归丸化裁方、针灸联合序贯疗法治疗卵巢早衰的临床观察[J].世界中医药,2019,(09):. |
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| 右归丸化裁方、针灸联合序贯疗法治疗卵巢早衰的临床观察 |
| Clinical Observation on Sequential Therapy of Integrated Modified Yougui Pills and Acupuncture and Moxibustion on the Treatment of Premature Ovarian Failure |
| 投稿时间：2018-12-29 |
| DOI：10.3969/j.issn.1673-7202.2019.09.057 |
| 中文关键词: 卵巢早衰 右归丸化裁方 针灸 序贯疗法 卵巢功能 卵巢血流动力学 性激素 |
| English Keywords:Premature ovarian failure Modified Yougui Pills Acupuncture and moxibustion Sequential therapy Ovarian function Ovarian hemodynamics Sex hormones |
| 基金项目:山东省中医药科技发展计划项目（2013-124） |
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| 中文摘要: |
| 目的：探讨右归丸化裁方、针灸联合序贯疗法治疗卵巢早衰的临床效果及对卵巢功能、卵巢血流动力学、性激素水平的影响。方法：选取2017年3月至2018年9月聊城市人民医院收治的卵巢早衰患者126例作为研究对象，按照随机数字表法分为对照组和观察组，每组63例。对照组患者给予序贯疗法，观察组患者则在此基础上加用右归丸化裁方、针灸联合治疗。通过评价中医证候积分比较2组治疗的临床效果，用改良Kupperman症状评分评估治疗前后围绝经期症状；检测治疗前后卵巢功能、卵巢血流动力学指标、性激素水平变化。结果：观察组有效率90.48%，明显高于对照组的有效率77.78%，差异有统计学意义（P<0.05）；治疗后，观察组患者的临床症状改善较对照组明显，中医证候积分、Kupperman评分均明显低于对照组，卵巢功能改善优于对照组，卵巢功能指标AFC、OAV、MOD均较对照组明显升高，差异有统计学意义（P<0.05）；卵巢血流动力学指标PI、RI均较对照组明显降低，PSV水平明显升高，差异有统计学意义（P<0.05）；激素E2水平明显高于对照组，FSH、LH水平明显低于对照组，差异有统计学意义（P<0.05）。结论：右归丸化裁方、针灸联合序贯疗法利于减轻卵巢早衰患者的临床症状，改善卵巢储备功能，促进卵巢局部微循环，有效调节内分泌激素水平，值得临床推广应用。 |
| English Summary: |
| To discuss the clinical effect of sequential therapy of integrated Yougui Pills and acupuncture and moxibustion on the treatment of premature ovarian failure and its effect on ovarian function,ovarian hemodynamics and sex hormone levels.Methods:From March 2017 to September 2018,126 cases of premature ovarian failure patients admitted to Liaocheng People's Hospital were selected as the research objects,and were divided into a control group and an observation group,with 63 cases in each group by random number table method.Patients in the control group were given sequential therapy,while patients in the treatment group were treated with Yougui Pills and acupuncture on the basis of control therapy.The clinical effects were compared by observing the 2 groups of traditional Chinese medicine syndrome scores before and after treatment.The perimenopausal symptoms were evaluated by the modified Kupperman index,and the changes of ovarian function,ovarian hemodynamic index and sex hormone level were detected before and after treatment.Results:The effective rate of the treatment group was 90.48%,which was significantly higher than that of the control group of 77.78%(P<0.05).After treatment,the clinical symptoms of patients in the treatment group were significantly improved than those in the control group.The traditional Chinese medicine syndrome scores and Kupperman scores were significantly lower than those in the control group,and the improvement of ovarian function was higher than those in the control group.The AFC,OAV and MOD of ovarian function indicators were all significantly higher than those in the control group(P<0.05); The ovarian hemodynamic indexes PI and RI were significantly lower than those of the control group,and the PSV level significantly increased(P<0.05).The levels of hormone E2 were significantly higher than those of the control group,and the FSH and LH level were significantly lower than those of the control group(P<0.05).Conclusion:Sequential therapy of integrated Yougui Pills,acupuncture and moxibustion are beneficial to alleviate the clinical symptoms of patients with premature ovarian failure,improve ovarian reserve function,promote local microcirculation of the ovary,and effectively regulate the level of endocrine hormones,which are worthy of clinical promotion and application. |
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