| 引用本文:王景，于洋，张海丽.针灸联合蕲蛇酶注射液治疗血栓闭塞性脉管炎的临床随机对照研究[J].世界中医药,2019,(09):. |
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| 针灸联合蕲蛇酶注射液治疗血栓闭塞性脉管炎的临床随机对照研究 |
| Randomized Controlled Clinical Trial of Acupuncture and Moxibustion Combined with Acutobin Injection in the Treatment of Thromboangiitis Obliterans |
| 投稿时间：2018-08-20 |
| DOI：10.3969/j.issn.1673-7202.2019.09.058 |
| 中文关键词: 针灸 蕲蛇酶注射液 血栓闭塞性脉管炎 临床价值 |
| English Keywords:Acupuncture Acutobin Injection Thromboangiitis obliterans Clinical value |
| 基金项目:黑龙江省自然科学基金项目（H2017067）；黑龙江省教育厅科学研究计划资助项目(D2017820) |
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| 中文摘要: |
| 目的：探究针灸联合蕲蛇酶注射液治疗血栓闭塞性脉管炎的临床价值，为丰富临床方法提供参考依据。方法：选取2015年2月至2018年6月黑龙江中医药大学附属第二医院收治的血栓闭塞性脉管炎患者100例作为研究对象，采用随机数字表法随机分为对照组和观察组，每组50例。对照组给予常规处理同时采用蕲蛇酶注射液治疗，观察组在对照组治疗的基础上加用针灸治疗。2组患者均同时治疗4周，观察2组患者治疗前、治疗2周后、治疗4周后的疗效和血液流变学等指标变化情况。结果：2组患者治疗前肢体发凉、静息痛、间歇性跛行、肤色异常、高切血黏度、低切血黏度、血浆比黏度、红细胞聚集指数、IgA、IgG、IgM比较，差异均无统计学意义（P>0.05）。治疗2周、4周后，2组患者上述指标均较治疗前显著改善，且观察组上述指标均明显优于对照组（P<0.05）。治疗4周后观察组临床治愈率、总有效率显著优于对照组（P<0.05）。结论：针灸联合蕲蛇酶注射液能通过促进血液循环，提高机体免疫力，改善血栓闭塞性脉管炎的临床症状，从而提高疗效，可作为该疾病常规治疗手段。 |
| English Summary: |
| To explore the clinical value of acupuncture and moxibustion combined with Acutobin Injection in treating thromboangiites obliterans，so as to provide reference for enriching clinical practice.Methods:A total of 100 patients with thromboangiites obliterans who were hospitalized in The Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine from February 2015 to June 2018 were selected as research objects.According to the order of admission，the patients were divided into control group(50 cases）and observation group(50 cases）by random number table.The control group was treated with routine treatment and Acutobin Injection treatment.The observation group was also treated with acupuncture and moxibustion on the basis of the treatment in the control group.All the patients were treated at the same time for 4 weeks.Index changes of efficacy and blood rheology were observed before the treatment，after 2 weeks of the treatment，and after 4 weeks of the treatment.Results:Before the treatment，there was no significant difference between the 2 groups of patients in limb cold，rest pain，intermittent claudication，abnormal complexion，high shear blood viscosity，low shear blood viscosity，plasma specific viscosity，erythrocyte aggregation，IgA，IgG and IgM(P>0.05).After 2 weeks and 4 weeks of the treatment，the above indexes of the 2 groups were significantly improved compared with those before the treatment，and the above indexes in the observation group were significantly better than those in the control group(P<0.05).After 4 weeks of the treatment，the clinical cure rate and total effective rate in the observation group were significantly better than those in the control group(P<0.05).Conclusion:Acupuncture and moxibustion combined with Acutobin Injection can promote blood circulation，improve immunity of the body，improve clinical symptoms of thromboangiitis obliterans，and thus improve the efficacy.It can be used as a routine treatment for the disease. |
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