| 引用本文:刘艳华，张静，孙艳，徐帅.针灸联合康复治疗对脑梗死患者神经功能恢复、血清细胞因子分泌的影响[J].世界中医药,2019,(09):. |
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| 针灸联合康复治疗对脑梗死患者神经功能恢复、血清细胞因子分泌的影响 |
| Effects of Acupuncture and Moxibustion Combined with Rehabilitation on Neurological Function Recovery and Serum Cytokines Secretion in Patients with Cerebral Infarction |
| 投稿时间：2018-08-28 |
| DOI：10.3969/j.issn.1673-7202.2019.09.060 |
| 中文关键词: 脑梗死 针灸 康复治疗 神经功能 炎性反应因子 血管新生 |
| English Keywords:Cerebral infarction Acupuncture and moxibustion Rehabilitation therapy Nerve function Inflammatory factors Angiogenesis |
| 基金项目:山东省卫生厅青年科研基金项目(9622） |
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| 中文摘要: |
| 目的：探讨针灸联合康复治疗对脑梗死患者神经功能恢复、血清细胞因子分泌的影响。方法：选取2015年9月至2018年2月枣矿集团中心医院收治的急性脑梗死患者176例作为研究对象，按照康复期治疗方案分为对照组（n=90）和观察组（n=86），对照组接受常规康复治疗，观察组接受针灸联合常规康复治疗，均以4周为1个疗程。比较2组康复治疗后神经功能恢复情况以及血清炎性反应因子［白细胞介素-6（IL-6）、白细胞介素-18（IL-18）、肿瘤坏死因子α（TNF-α）］、血管新生指标［碱性成纤维细胞生长因子（bFGF）、血管内皮生长因子（VEGF）、基质金属蛋白酶-9（MMP-9）］情况。结果：治疗1个疗程、治疗2个疗程后，观察组NIHSS评分值分别为（16.15±2.24）分、（7.37±0.91）分，分别低于对照组的（22.73±2.85）分、（15.09±2.21）分，差异有统计学意义（P<0.05）。治疗2疗程后，观察组血清中IL-6、IL-18、TNF-α的含量为（4.18±0.52）pg/mL、（8.77±1.03）pg/mL、（9.92±1.53）pg/mL，分别低于对照组的（7.43±0.89）pg/mL、（12.01±1.55）pg/mL、（14.28±1.69）pg/mL，差异有统计学意义（P<0.05）；观察组血清中bFGF、VEGF、MMP-9的含量为（19.77±2.84）pg/mL、（374.18±45.39）pg/mL、（54.25±7.49）ng/mL，分别高于对照组的（14.69±1.73）pg/mL、（316.21±39.74）pg/mL、（48.27±6.28）ng/mL，差异有统计学意义（P<0.05）。结论：脑梗死康复期患者在常规康复治疗基础上加入中医针灸治疗，可进一步减轻患者的神经功能缺损程度，具体作用机制可能与针灸减轻患者炎性反应并促进血管新生等相关。 |
| English Summary: |
| To explore effects of acupuncture and moxibustion combined with rehabilitation on neurological function recovery and serum cytokines secretion in patients with cerebral infarction.Methods:A total of 176 cases of acute cerebral infarction patients underwent treatment in the Central Hospital of Zaokuang Group during September 2015 to February 2018 were collected as research subjects and retrospectively analyzed.According to the rehabilitative treatment plans，the patients were divided into control group(n＝90，underwent routine rehabilitation)，and observation group(n＝86，underwent acupuncture and moxibustion combined with conventional rehabilitation treatment)，taking 4 weeks as 1 course of treatment.The recovery of nerve function，serum inflammatory factors ［interleukins-6(IL-6)，interleukin-18(IL-18）and tumor necrosis factor-α(TNF-α)］ and angiogenesis indexes ［basic fibroblast growth factor(bFGF)，vascular endothelial growth factor(VEGF）and matrix metalloproteinase-9(MMP-9)］ were compared between the 2 groups after the rehabilitative treatment.Results:After 1 and 2 courses of the treatment，NIHSS score in the observation group was(16.15±2.24）and(7.37±0.91)，which were respectively lower than the control group's(22.73±2.85）and(15.09±2.21)，and the difference was statistically significant(P<0.05).After 2 courses of the treatment，the serum IL-6，IL-18 and TNF-α in the observation group were(4.18±0.52）pg/mL，(8.77±1.03）pg/mL and(9.92±1.53）pg/mL，which were respectively lower than the control group's(7.43±0.89）pg/mL，(12.01±1.55）pg/mL and(14.28±1.69）pg/mL，and the difference was statistically significant(P<0.05).the serum bFGF，VEGF and MMP-9 in the observation group were(19.77±2.84）pg/mL，(374.18±45.39）pg/mL and(54.25±7.49）ng/mL，which were respectively higher than the control group's(14.69±1.73）pg/mL，(316.21±39.74）pg/mL and(48.27±6.28）ng/mL，and the difference was statistically significant(P<0.05).Conclusion:Acupunture and moxibustion of traditional Chinese medicine on the basis of conventional rehabilitation in patients with cerebral infarction can further reduce their nerve function defects.The specific mechanism may be related to relieving patients' inflammatory response，promoting angiogenesis，etc. |
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