| 引用本文:巴元明1，3，胡刚明2，王林群2，李玉婷2，刘静琰2，艾中柱2.基于大黄不同炮制方法和煎煮时间治疗慢性肾衰竭患者的理论探讨[J].世界中医药,2019,(09):. |
|
| 基于大黄不同炮制方法和煎煮时间治疗慢性肾衰竭患者的理论探讨 |
| Theoretical Study on Treatment of Chronic Renal Failure Based on Different Processing Methods and Decocting Time of Radix et Rhizoma Rhei |
| 投稿时间：2018-09-18 |
| DOI：10.3969/j.issn.1673-7202.2019.09.068 |
| 中文关键词: 大黄 炮制 煎煮 肾功能 慢性肾衰竭 转化生长因子-β1 经验 |
| English Keywords:Radix et Rhizoma Rhei Different processing methods Different decocting time Chronic renal failure Experience Renal function TGF-β1 PI3k Akt |
| 基金项目:湖北省中西医结合科研重点项目（鄂卫生计生通［2017］20号） |
|
| 摘要点击次数: 527 |
| 全文下载次数: 453 |
| 中文摘要: |
| 中药大黄在慢性肾衰竭（CRF）患者的治疗中发挥着重要的作用，能有效延缓肾脏病的进展。通过讨论大黄通腑降浊在慢性肾衰竭的运用，探讨大黄治疗CRF的作用机制，大黄不同炮制方法和煎煮时间对有效成分及功效的影响，名老中医使用大黄治疗CRF的经验，大黄对CRF肾小球硬化信号通路的影响。生大黄、熟大黄、酒大黄、大黄炭哪一种是治疗CRF的最佳药物；不同炮制方法和煎煮时间对大黄有效成分的影响；煎煮多长时间才能发挥最大疗效；大黄治疗CRF的作用机制。现研究大黄不同炮制品不同煎煮时间有效成分的变化规律和大黄不同炮制品不同煎煮时间对CRF大鼠转化生长因子-β1/P13K/Akt信号旁路的影响，为大黄的临床应用提供理论依据。 |
| English Summary: |
| Radix et Rhizoma Rhei plays an important role in the treatment of chronic renal failure(CRF)，which can effectively delay the progress of kidney disease.The aim of this paper is to discuss the application of Radix et Rhizoma Rhei's catharsis and descending the turbid in CRF，action mechanism of Radix et Rhizoma Rhei in treating CRF，the effects of different processing methods and decocting time of Radix et Rhizoma Rhei on active ingredients and efficacy，experience of famous TCM doctors in treating CRF with Radix et Rhizoma Rhei，effects of Radix et Rhizoma Rhei on CRF glomerulosclerosis signal pathway.Several questions were found：raw Radix et Rhizoma Rhei，Rehmanniae Radix Praeparata，wine processed Radix et Rhizoma Rhei and stir-fried Radix et Rhizoma Rhei，which is the best herb for the treatment of CRF? What is the effect of different processing methods and decocting time on the effective components of Radix et Rhizoma Rhei? How long does decocting take to get the best effect? What is the mechanism of Radix et Rhizoma Rhei in the treatment of CRF? This paper is intended to study the change rule of effective components in different processed products of Radix et Rhizoma Rhei and the influence of different decocting time of Radix et Rhizoma Rhei on the TGF-1/P13K/Akt signaling pathway of CRF rats，hoping to provide a theoretical basis for clinical application of Radix et Rhizoma Rhei. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
