| 引用本文:廖宗力1，孙璐1，黄文韬2，朱重政3，谭静1，阳仁达1.不同促透剂运用于隔药饼灸对高脂血症兔血脂及炎性反应因子的调节作用[J].世界中医药,2019,(10):. |
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| 不同促透剂运用于隔药饼灸对高脂血症兔血脂及炎性反应因子的调节作用 |
| Regulatory Effects of Different Penetration Enhancers Applied with Herbal Cake-Partitioned Moxibustion on the Levels of Blood Lipids and Inflammatory Factors of a Hyperlipidemia Rabbit Model |
| 投稿时间：2019-04-19 |
| DOI：10.3969/j.issn.1673-7202.2019.10.013 |
| 中文关键词: 高脂血症 隔药饼灸 透皮吸收促进剂 经皮给药系统 炎性反应因子 氮酮 冰片 |
| English Keywords:Hyperlipidemia Herbal cake-partitioned moxibustion Penetration enhancer Transdermal drug delivery Inflammatory factor Azone Borneol |
| 基金项目:湖南省高校创新平台开放基金项目(16K068)；湖南省研究生科研创新项目(CX2017B431) |
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| 中文摘要: |
| 目的:氮酮和冰片作为促透剂运用于药饼中对高脂血症兔进行隔药饼施灸,观察其对高脂血症兔血脂及炎性反应因子的调节作用。方法:将40只新西兰兔随机分为正常组、高脂模型组、无促透剂组、氮酮组和冰片组,每组8只。正常组普通饲料喂养,其余各组用高脂饲料喂养12周成高脂模型,成模后采用不同促透剂运用于隔药饼灸施灸4周后,检测兔血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)及TNF-α、INF-γ的含量。结果:3个隔药饼灸组均显著降低高脂模型兔血清TC、TG、LDL-C的含量(P<0.05)、显著升高HDL-C的含量(P<0.05);氮酮组降低TC和TG、冰片组降低TC、TG、LDL-C的效果优于无促透剂组(P<0.05);冰片组降低TC、TG、LDL-C的效果优于氮酮组(P<0.05);3个隔药饼灸组均能显著降低高脂血症兔TNF-α及INF-γ的水平(P<0.05),且氮酮组和冰片组降低TNF-α、INF-γ的疗效优于无促透剂组(P<0.05),冰片组降低TNF-α的效果优于氮酮组(P<0.05)。结论:隔药饼灸能有效调节高脂模型兔血脂及炎性反应因子水平,氮酮和冰片作为促透剂运用于药饼后施灸对实验性高脂模型兔血脂及炎性反应因子的调节作用更显著,且冰片组作用比氮酮组更优,值得进一步研究。 |
| English Summary: |
| To study the regulatory effect of penetration enhancers Azone and borneol applied with herbal cake-partitioned moxibustion on blood lipid and inflammatory factor levels，and to observe the regulatory effects on the levels of blood lipids and inflammatory factors of a hyperlipidemia rabbit model.Methods:A total of 40 New Zealand white rabbits were randomly divided into a normal group，a hyperlipidemia group，a moxibustion treated only hyperlipidemia group，an Azone plus moxibustion treated hyperlipidemia group and a borneol plus moxibustion treated hyperlipidemia group，with 8 rabbits each.The normal group rabbits were feed normally，whereas other rabbits were firstly treated with high-fat food for 12 weeks to generate hyperlipidemia model，followed by treatment of herbal cake-partitioned moxibustion applied with penetration enhancers for 4 weeks.Afterwards，rabbit serum was collected and measured for levels of total cholesterol(TC)，tryglyceride(TG)，high-density lipoprotein cholesterol(HDL-C)，low-density lipoprotein cholesterol(LDL-C)，TNF-α，and INF-γ.Results:All the 3 herbal cake-partitioned moxibustion groups significantly reduced blood TC，TG and LDL-C(P<0.05)，and significantly increased HDL-L(P<0.05).The effect of the Azone group decreasing TC and TG，and the borneol group decreasing blood TC，TG and LDL-C levels was better than no penetration enhancers group(P<0.05).The borneol group was better than the Azone group in reducing TC(P<0.05).The 3 herbal cake-partitioned moxibustion groups significantly reduced blood TNF-α，and INF-γ levels(P<0.05)，and the Azone group and the borneol group were better than no penetration enhancers group(P<0.05).The borneol group was better than the Azone group in reducing TNF-α(P<0.05).Conclusion:Herbal cake-partitioned moxibustion can effectively regulate the blood lipid and inflammatory factors in the high-fat model rabbits.The application of Azone and borneol，as a penetration enhancer，have more significant regulatory effect on the levels of blood lipids and inflammatory factors of a hyperlipidemia rabbit model after herbal cake-partitioned moxibustion，and the Azone group was better than the borneol group，which deserves further study. |
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