世界中医药
文章摘要
引用本文:孙天石,高妍,李卫红,于雪,刘燕,张凡,张楚焌,董一昕,宋月晗.镇惊温胆汤药物指纹图谱研究及对PTSD大鼠行为学影响的实验观察[J].世界中医药,2019,(10):.  
镇惊温胆汤药物指纹图谱研究及对PTSD大鼠行为学影响的实验观察
Study on Fingerprint of Zhenjing Wendan Decoction and Experimental Observation on Its Effects on the Behavior of Rats with Post-Traumatic Stress Disorder
投稿时间:2018-05-16  
DOI:10.3969/j.issn.1673-7202.2019.10.015
中文关键词:  镇惊温胆汤  创伤后应激障碍  单次延长应激  旷场试验  僵立行为  超高效液相色谱  帕罗西汀  气机
English Keywords:Zhenjing Wendan Decoction  Post-traumatic stress disorder  Single-prolonged stress  Open Field Test  Freezing Time  Ultra Performance Liquid Chromatography  Paroxetine  Qi movement
基金项目:新奥奖励基金课题(2016XAJLJJ-008)
作者单位
孙天石,高妍,李卫红,于雪,刘燕,张凡,张楚焌,董一昕,宋月晗 北京中医药大学,北京,100029 
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中文摘要:
      目的:通过SPS模型建立大鼠PTSD模型,研究镇惊温胆汤对SPS模型大鼠的影响。方法:将40只大鼠随机分为正常组、模型组、镇惊温胆汤组和帕罗西汀组,后3组给予SPS造模,之后连续灌胃7 d。结束后检测旷场实验和僵立行为测试。结果:与模型组比较镇惊温胆汤、帕罗西汀组,在大鼠运动总距离,最大运动距离,穿格次数等多个指标上都出现了明显的区别,尤其是在僵立时间方面差异有统计学意义(P<0.01),其中镇惊温胆汤对大鼠产生了显著的作用,使得该组在最长运动距离,直立次数,单次最大运动距离等多个指标(P<0.01),作用优于帕罗西汀组,但在大鼠僵立时间方面与帕罗西汀组比较,差异无统计学意义。结论:本实验成功通过单次延长应激复了创伤后应激障碍大鼠模型,镇惊温胆汤使得SPS模型焦虑和恐惧状态得到改善。
English Summary:
      To establish a rat model of post-traumatic stress disorder(PTSD)through single-prolonged stress(SPS)and to observe the effect of Zhenjing Wendan Decoction on the behavior of the SPS model rats.Methods:A total of 40 rats were randomly divided into a normal group,a model group,a Zhenjing Wendan Decoction group and a Paroxetine group.The rats in the last 3 groups were modeled by SPS.And then the rags were receiving gavage for 7 days.After that,Open Field Test and Freezing Time Test were performed.Results:Compared with the model group,all groups except the normal group had significant differences in several indicators,such as the total distance of movement,maximum distance of movement and the number of grid penetration,especially in freezing time(P<0.05).Among them,Zhenjing Wendan Decoction had significant difference,making the indicators of maximum distance of movement,erect times,and single movement distance better than the Paroxetine group,but there was no significant difference in freezing time.Conclusion:This study succeeded repairing PTSD model rats through SPS.Zhenjin Wendan improved the anxiety and fear state of SPS model.
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