| 引用本文:吴红艳1，黄飞翔2，贾涔琳1，张治芬1，魏双双2，金雪静2，黄坚2.益癸方联合芬吗通治疗围绝经期综合征的疗效研究[J].世界中医药,2019,(10):. |
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| 益癸方联合芬吗通治疗围绝经期综合征的疗效研究 |
| Study on the Effects of Yigui Decoction Combined with Femoston on Perimenopausal Syndrome |
| 投稿时间：2019-02-20 |
| DOI：10.3969/j.issn.1673-7202.2019.10.023 |
| 中文关键词: 益癸方 芬吗通 围绝经期综合征 肝酶 Kupperman评分 |
| English Keywords:Yigui Decoction Femoston Perimenopausal syndrome Liver enzyme Kupperman score |
| 基金项目:国家卫生计划和生育委员会科研基金项目(WKJ2013-2-024);浙江省科技厅重大科技专项重点社会发展项目(2014C03044-1);杭州市医药卫生科技计划重点项目(2011Z003);浙江省中医药科技计划重点项目(2014ZZ009) |
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| 中文摘要: |
| 目的:探讨益癸方联合芬吗通治疗围绝经期综合征的疗效。方法:选取2015年1月至2017年12月南京医科医科大学附属杭州医院收治的围绝经期妇女266例作为研究对象,按照治疗不同的治疗方法分为西药组(芬吗通)（n＝85）、中药组(益癸方)（n＝61）、中西药组(同时服用芬吗通和益癸方)（n＝80）。比较分析治疗前后3组患者的Kupperman评分及FSH、LH、E2、TC、TG、HDL、LDL、ALT、AST水平。结果:初诊时3组患者Kupperman评分,FSH、LH、E2、血脂水平、肝酶水平比较，差异均无统计学意义(均P>0.05)。治疗3个月后,与治疗前比较,3组患者FSH、LH、LDL水平及Kupperman评分显著下降,E2水平显著升高,差异均有统计学意义(均P<0.05);3组患者肝酶水平无显著变化,差异均无统计学意义(均P>0.05)。中西药组与西药组、中药组比较,Kupperman评分及FSH水平下降更为显著,且西药组疗效优于中药组,差异均有统计学意义(均P<0.05)。结论:中药益癸方、西药芬吗通及两者的联合治疗均可改善围绝经期症状,降低FSH、LDL水平,且对肝功能无显著影响,而益癸方联合芬吗通的治疗方案疗效更为显著。 |
| English Summary: |
| To explore the effect of Yigui Decoction combined with Femoston on perimenopausal syndrome.Methods:The 266 cases of perimenopausal women were recruited from the gynecology outpatient in the Hangzhou Women's Hospital from January 2015 to December 2017.They were divided into a western medicine group(Femoston)of 85 cases，a Chinese medicine group(Yigui Decoction)of 61 cases，and a Chinese medicine and western medicine group(taking both Femoston and Yigui Decoction)of 80 cases according to different treatment methods.Kupperman Mnopause Index(KMI)，follicle stimulating hormone(FSH)，luteinizing hormone(LH)，estradiol(E2),TC，TG，HDL，LDL，ALT，AST were measured before and after 3 months treatment，respectively.Results:There were no significant differences in the FSH，LH，E2，blood lipid levels，liver enzyme levels and Kupperman scores in the 3 groups before treatment(all P>0.05).The FSH，LH，LDL levels and Kupperman scores were significantly decreased while E2 level was increased obviously after 3 months treatment compared with those before treatment in the 3 groups(all P<0.05).And there were no significant change in liver enzyme levels in the 3 groups(all P>0.05).Compared with the western medicine group and the Chinese medicine group，Kupperman score and FSH level in the Chinese medicine and western medicine group were significantly decreased.The effects of western medicine group were better than those of Chinese medicine group，and the difference was statistically significant(all P<0.05).Conclusion:Chinese medicine Yigui Decoction，western medicine Femoston and combination of both all can improve perimenopausal syndrome，decrease FSH，LDL levels，and has no significant effects on liver function.The treatment of Yigui Decoction combined with Femoston is more effective. |
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