| 引用本文:张刚1，周崇文2，柴星宇3.脉络舒通丸对下肢深静脉血栓疗效观察及对炎性反应因子的影响[J].世界中医药,2019,(10):. |
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| 脉络舒通丸对下肢深静脉血栓疗效观察及对炎性反应因子的影响 |
| Efficacy Observation on Mailuo Shutong Pills in Deep Venous Thrombosis of Lower Limb and Its Effects on Inflammatory Factors |
| 投稿时间：2019-03-02 |
| DOI：10.3969/j.issn.1673-7202.2019.10.026 |
| 中文关键词: 脉络舒通丸 深静脉血栓 炎性反应因子 临床疗效 不良反应 临床对照研究 中医药 |
| English Keywords:Mailuo Shutong Pills Deep venous thrombosis Inflammatory factors Clinical efficacy Adverse reactions Clinical controlled study Traditional Chinese medicine |
| 基金项目:国家自然科学基金项目（39170723）——恢复下肢深静脉倒流和回流障碍病变血流动力学状态研究 |
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| 中文摘要: |
| 目的：探讨脉络舒通丸对深静脉血栓的疗效及对炎性反应因子的影响。方法：选取2017年8月至2019年3月解放军联勤保障部队第960医院收治的下肢深静脉血栓患者76例作为研究对象，按照随机数字表法分为对照组和观察组，每组38例。对照组患者采用绝对的卧床休息，患肢抬高于床面约30 cm，与床面呈约30°，嘱托严禁进行按压和热敷，保持绝对制动，仅配合服用肠溶阿司匹林及空白安慰剂等基础治疗措施，不采用其他任何消肿、镇痛药物。观察组患者在对照组治疗的基础上，给予口服脉络舒通丸治疗，口服每次1瓶，3次/d，7 d为1个疗程。每个疗程结束测量患者患肢周径、疼痛感、色素沉着评分和血液中C-反应蛋白(CPR)、白细胞介素1β(IL-1β）、白细胞介素6（IL-6)和纤维蛋白原(FBI)4个炎性反应因子水平，患者所有指标连续2个疗程稳定后视为稳定疗效。结果：2组患者在疗程结束后总治愈率有明显差别，观察组总治愈率为78.94%，优于对照组的总治愈率52.26%，平均治愈时间分别为(18.6±3.2)d、(30.8±5.4)d，差异有统计学意义（P<0.05）。观察组患者的临床指标和C-反应蛋白CPR、白细胞介素IL-1β、IL-6和纤维蛋白原FBI 4种炎性反应因子水平均优于对照组，差异有统计学意义（P<0.05）。观察组不良反应发生率与对照组比较，差异无统计学意义（P>0.05）。结论：脉络舒通丸治疗深静脉血栓的疗效显著，可明显降低血液中炎性反应因子水平，并具有很高的安全性。 |
| English Summary: |
| To explore efficacy of Mailuo Shutong Pills in deep venous thrombosis and its effects on inflammatory factors.Methods:A total of 76 patients with deep venous thrombosis of lower limb admitted in No.960 Hospital of The PLA Joint Logistic Support Force from August 2017 to March 2019 were selected as subjects and divided into control group and observation group according to random number table method，with 38 patients in each group.Patients in the control group were treated with absolute bed rest.Affected limbs were raised about 30 cm above the bed surface and about 30° from the bed surface.Pressing and hot compressing were strictly prohibited，and absolute braking was maintained.Only basic treatment like enteric-coated aspirin and blank placebo were used.There were no other drugs for detumescence or analgesia applied.Patients in the observation group were given Mailuo Shutong Pills orally on the treatment basis of the control group.One bottle per oral administration，3 times/d，and 7 d was 1 course of treatment.At the end of each course of the treatment，affected limb circumference of the patient，pain sensation，pigmentation score，and levels of 4 inflammatory factors：C-reactive protein(CPR)，interleukin 1β(IL-1β)，interleukin 6(IL-6)and fibrinogen(FBI)in the blood were measured.Stability of all the indicators of the patient after 2 consecutive courses of the treatment was considered as stable efficacy.Results:In the 2 groups，total cure rates were significantly different after the treatment.The total cure rate in the observation group was 78.94%，which was better than 52.26% in the control group.And average cure time in the 2 groups was(18.6±3.2)d and(30.8±5.4)d，separately.The difference was statistically significant(P<0.05).The clinical indexes and the levels of the 4 inflammatory factors：CPR，IL-1β，IL-6 and FBI in the observation group were superior to those in the control group，and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusion:The efficacy of Mailuo Shutong Pills in treating deep venous thrombosis is significant，which can significantly decrease the level of inflammatory factors in the blood and has high safety. |
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