| 引用本文:喜雷1，史彦香2，宋毅3，姜艳玲3，孙成磊3.柴银口服液与奥司他韦治疗小儿上呼吸道感染疗效比较分析[J].世界中医药,2019,(10):. |
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| 柴银口服液与奥司他韦治疗小儿上呼吸道感染疗效比较分析 |
| Comparative Analysis on Efficacy of Chaiyin Oral Liquid and Oseltamivir in the Treatment of Upper Respiratory Tract Infection in Children |
| 投稿时间：2019-05-08 |
| DOI：10.3969/j.issn.1673-7202.2019.10.027 |
| 中文关键词: 小儿上呼吸道感染 柴银口服液 奥司他韦 T淋巴细胞 临床疗效 不良反应 |
| English Keywords:Upper respiratory tract infection in children Chaiyin Oral Liquid Oseltamivir T lymphocytes Clinical efficacy Adverse reaction |
| 基金项目:国家中医药管理局“十一五”重点专科建设项目(09J1X1L115K122) |
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| 中文摘要: |
| 目的：比较分析柴银口服液与奥司他韦治疗小儿上呼吸道感染的临床疗效。方法：选取2016年12月至2018年12月通州区妇幼保健院收治的上呼吸道感染患儿80例作为研究对象，按照随机数字表法随机分为观察组和对照组，每组40例。观察组采用柴银口服液治疗，对照组患儿服用奥司他韦治疗，持续治疗7 d。观察2组临床疗效及T淋巴细胞亚群（CD3+、CD4+、CD8+）水平变化情况，同时记录和比较2组患儿咳嗽消失时间、发热消退时间、咽喉部充血消失时间及不良反应发生率。结果：治疗后，观察组总有效率为92.5%（37/40）；对照组总有效率为85%（34/40）；观察组总有效率高于对照组，2组比较差异无统计学意义（P>0.05）。治疗后2组患者CD3+、CD4+水平均不同程度的提高，且观察组均高于对照组，而CD8+水平下降。治疗前，2组比较差异无统计学意义（P>0.05）；治疗后，2组比较差异有统计学意义（P<0.05）。观察组咳嗽消失时间、发热消退时间低于对照组，咽喉部充血消失时间高于对照组，2组比较差异无统计学意义（P>0.05）。观察组不良反应发生率仅为5%，对照组为15%。结论：柴银口服液在临床体征消退时间上与奥司他韦效果类似，临床总有效率高于奥司他韦，在免疫功能恢复上效果显著且不良反应发生率较低，更加具有临床应用价值。 |
| English Summary: |
| To compare and analyze clinical efficacy of Chaiyin Oral Liquid and oseltamivir in the treatment of children upper respiratory tract infection.Methods:A total of 80 cases of children with upper respiratory tract infection admitted in Tongzhou Maternal & Child Health Hospital of Beijing from December 2016 to December 2018 were selected as subjects and divided into observation group and control group according to random number table method，with 40 patients in each group.The observation group was given Chaiyin Oral Liquid，and the control group was given oseltamivir.They were treated for 7 d.The clinical efficacy and level changes of T lymphocyte subsets(CD3+，CD4+ and CD8+)in the 2 groups were observed.Meanwhile，cough disappearance time，fever recession time，throat congestion disappearance time and incidence of adverse reactions in the 2 groups were recorded and compared.Results:After the treatment，the total effective rate in the observation group reached 92.5%(37/40)，and the total effective rate in the control group reached 87.5%(34/40).The total effective rate in the observation group was higher than that in the control group，and the difference between the 2 groups was not statistically significant(P>0.05).After the treatment，the levels of CD3+ and CD4+ in the 2 groups were increased to different degrees，and the levels in the observation group were higher than those in the control group，while the levels of CD8+ were decreased.The comparison before the treatment in the 2 groups was not statistically significant(P>0.05)，while the difference after the treatment was statistically significant(P<0.05).The disappearance time of cough and fever in the observation group was lower than that in the control group，and the disappearance time of throat congestion was higher than that in the control group.There was no statistically significant difference between the 2 groups(P>0.05).The incidence of adverse reactions in the observation group was only 5%，while that in the control group was up to 15%.Conclusion:Chaiyin Oral Liquid is similar to oseltamivir in the clinical sign disappearance time，and its clinical total effective rate is higher than that of oseltamivir.It has a significant effect in the recovery of immune function and a low incidence of adverse reactions，so it has more clinical application value. |
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