| 引用本文:陈鹏，于震寰，陈曦.温阳强心汤对阳虚水泛型慢性心力衰竭患者血浆IL-27、hsCRP及NT-proBNP的影响研究[J].世界中医药,2019,(10):. |
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| 温阳强心汤对阳虚水泛型慢性心力衰竭患者血浆IL-27、hsCRP及NT-proBNP的影响研究 |
| Study on the Effect on IL-27,hsCRP and NT-proBNP in Patients with Chronic Heart Failure of Yang Deficiency and Edema Type Using Wenyang Qiangxin Decociton |
| 投稿时间：2019-04-11 |
| DOI：10.3969/j.issn.1673-7202.2019.10.033 |
| 中文关键词: 慢性心力衰竭 温阳强心汤 IL-27 NT-proBNP |
| English Keywords:Chronic heart failure Wenyang Qiangxin Decoction IL-27 NT-proBNP |
| 基金项目:山东省医药卫生科技发展项目（2011BJYB25） |
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| 中文摘要: |
| 目的:探究温阳强心汤对阳虚水泛型慢性心力衰竭（CHF）患者血浆白细胞介素-27（IL-27）、超敏C-反应蛋白（hsCRP）和氨基末端脑钠肽前体（NT-proBNP）的影响。方法:选取2016年10月至2018年1月黑龙江中医药大学附属第一医院收治的阳虚水泛型CHF患者80例作为研究对象,按照入院顺序随机分为对照组和观察组，每组40例。对照组采用改善心功能、扩张心血管、渗水利尿等常规治疗方案；观察组加用本院自拟的温阳强心汤，2组患者疗程均为4周。比较2组患者治疗前后中医证候积分及治疗后总有效率、IL-27、hsCRP和NT-proBNP水平并计算分析其相关性。结果：治疗后，观察组总有效率为92.50%，显著高于对照组总有效率72.50%（P<0.05）；2组患者中医证候积分均显著降低（P<0.05），且2组差异有统计学意义（P<0.05）；观察组的hsCRP和NT-proBNP水平低于对照组（P<0.05）；而观察组的IL-27水平高于对照组（P<0.05）；IL-27与hsCRP和NT-proBNP呈负相关关系，且相关性差异有统计学意义（P<0.05）。结论：采用温阳强心汤对阳虚水泛型CHF疗效显著，能够有效改善心力衰竭症状，值得临床推广应用。 |
| English Summary: |
| To explore the effects on IL-27,hsCRP and NT-proBNP in patients with chronic heart failure(CHF)of yang deficiency and edema type using Wenyang Qiangxin Decociton.Methods:A total of 80 patients with CHF of yang deficiency and edema type from The First Affiliated Hospital of Heilongjiang University of Chinese Medicine were randomly divided into an observation group and a control group according to the order of admission,with 40 cases in each group.The control group used conventional treatment options such as improving heart function,dilating cardiovascular,promoting water and diuresis,while the observation group was added with self-made Wenyang Qiangxin Decoction.Both groups were treated with 4 weeks.The levels of IL-27,hsCRP,NT-proBNP,the scores of TCM syndromes and the total effective rates were compared between the 2 groups,and their correlation was calculated and analyzed.Results:After treatment,the total effective rate in the observation group was 92.50 %,which was significantly higher than 72.50% of the control group(P<0.05).After treatment,the scores of TCM syndromes in the 2 groups decreased significantly(P<0.05),and there was significant difference between the 2 groups(P<0.05).After treatment,the levels of hsCRP and NT-proBNP in the observation group were lower than those in the control group(P<0.05),while the level of IL-27 in the observation group was higher than that in the control group(P<0.05).IL-27 was negatively correlated with hsCRP and NT-proBNP,and the correlation was statistically significant(P<0.05).Conclusion:The Wenyang Qiangxin Decoction has an obvious curative effects on CHF of yang deficiency and edema type,and it can effectively improve the heart function,which is worthy for further clinical application. |
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