| 引用本文:禹宏1，刘宝生2，徐毛毛1，焦瑞芹1，王晓晓1，张宇1，王雨2，李伟莉3.五味消毒饮联合针刺下髎与交信穴治疗急性盆腔炎[J].世界中医药,2019,(10):. |
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| 五味消毒饮联合针刺下髎与交信穴治疗急性盆腔炎 |
| Effects of Wuwei Xiaodu Decoction Combined with Acupuncture at Xialao(BL34)and Jiaoxin(KI8)Points on Acute Pelvic Inflammatory Disease |
| 投稿时间：2019-03-29 |
| DOI：10.3969/j.issn.1673-7202.2019.10.047 |
| 中文关键词: 急性盆腔炎 五味消毒饮 针刺 炎性因子 T淋巴细胞亚群 下髎穴 交信穴 |
| English Keywords:Acute pelvic inflammatory disease Wuwei Xiaodu Decoction Acupuncture Inflammatory cytokines T lymphocyte subsets |
| 基金项目:安徽省卫生计生委中医药科研课题项目(2016zy51) |
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| 中文摘要: |
| 目的:探讨五味消毒饮联合针刺下髎与交信穴对急性盆腔炎(APID)患者炎性因子和T淋巴细胞亚群的影响。方法:选取2016年1月至2018年6月淮北市中医医院收治的APID患者103例作为研究对象,按照随机数字表法分为对照组(n=51)和观察组(n=52)。对照组给予常规治疗,观察组在对照组治疗的基础上给予五味消毒饮联合针刺下髎与交信穴治疗。评价并比较2组临床疗效,比较2组腹痛消失时间、体温恢复时间、白细胞计数(WBC)恢复时间及中性粒细胞比例(NEUT)恢复时间,比较2组治疗前后中医症状积分、WBC、NEUT、血清白细胞介素-6(IL-6)、C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、降钙素原(PCT)水平及外周血CD3+、CD4+、CD8+水平。记录2组治疗过程中不良反应的发生情况。结果:观察组的临床总有效率为94.23%(49/52),明显高于对照组的80.39%(41/51)(P<0.05)。观察组治疗后中医主要症状积分、次要症状积分均明显低于对照组(P<0.05)。观察组的腹痛消失时间、体温恢复时间、WBC恢复时间及NEUT恢复时间均明显短于对照组(P<0.05)。观察组治疗后血清IL-6、CRP、TNF-α、PCT、WBC、NEUT及外周血CD8+水平均明显低于对照组(P<0.05),外周血CD3+、CD4+水平均明显高于对照组(P<0.05)。2组治疗过程中均未发现严重的不良反应。结论:五味消毒饮联合针刺下髎与交信穴治疗APID的临床疗效显著,能够明显改善临床症状,降低炎性细胞因子水平,提高机体免疫功能,且安全性较好。 |
| English Summary: |
| To explore the effects of Wuwei Xiaodu Decoction combined with acupuncture at Xialao(BL34)and Jiaoxin(KI8)points on inflammatory cytokines and T lymphocyte subsets in patients with acute pelvic inflammatory disease(APID).Methods:A total of 103 patients with APID in Huaibei Hospital of Traditional Chinese Medicine from January 2016 to June 2018 were randomly divided into a control group(n＝51)and an observation group(n＝52).Patients in the control group were given conventional treatment,and the observation group was treated with Wuwei Xiaodu Decoction combined with acupuncture at Xialao(BL34)and Jiaoxin(KI8)points on the basis of the control group.The clinical efficacy of the 2 groups were evaluated and compared.The recovery time of abdominal pain,body temperature,white blood cell count(WBC)and neutrophil ratio(NEUT)were compared between the 2 groups.The TCM symptom score,WBC,NEUT,serum interleukin-6(IL-6),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),procalcitonin(PCT)levels and peripheral blood CD3+,CD4+,CD8+ levels were compared between the 2 groups before and after treatment.The occurrence of adverse reactions during the treatment was recorded.Results:The clinical efficacy rate of the observation group was 94.23%(49/52),which was significantly higher than 80.39%(41/51)of the control group(P<0.05).The scores of main symptoms and minor symptoms in the observation group after treatment were significantly lower than those in the control group(P<0.05).The abdominal pain disappear time,body temperature recovery time,WBC recovery time and NEUT recovery time of the observation group were significantly shorter than those of the control group(P<0.05).The levels of serum IL-6,CRP,TNF-α,PCT,WBC,NEUT and CD8+ in the observation group after treatment were significantly lower than those in the control group(P<0.05).The peripheral blood CD3+,CD4+ levels were significantly higher than those in the control group(P<0.05).There was no adverse reaction of the 2 groups during treatment.Conclusion:Wuwei Xiaodu Decoction combined with acupuncture at Xialao(BL34)and Jiaoxin(KI8)points in treatment of APID curative effect is significant.It can significantly improve clinical symptoms,reduce inflammatory cytokine levels,improve immune function,and has good safety. |
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