| 引用本文:张惠敏，任莹璐，苏聪平，王青，郭淑贞.中医药基于氧化应激治疗心力衰竭的应用[J].世界中医药,2019,(10):. |
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| 中医药基于氧化应激治疗心力衰竭的应用 |
| Application of Traditional Chinese Medicine in the Treatment of Heart Failure Based on Oxidative Stress |
| 投稿时间：2018-09-12 |
| DOI：10.3969/j.issn.1673-7202.2019.10.056 |
| 中文关键词: 心力衰竭 氧化应激 中医药 作用机制 抗氧化 心血管疾病 |
| English Keywords:Heart failure Oxidative stress,Traditional Chinese medicine |
| 基金项目:国家重点研发计划项目(2017YFC1700105)——气虚证的生物学基础研究 |
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| 中文摘要: |
| 心力衰竭(Heart Failure,HF)是各类心血管疾病的终末阶段,近年来随着高血压、冠心病等心血管疾病发病率的增加,最终发展为心力衰竭的人群也逐渐庞大。氧化应激(Oxidative Stress,OS)是指体内氧化与抗氧化作用失衡,导致中性粒细胞炎性浸润,蛋白酶分泌增加,产生大量氧化中间产物,对机体产生一种负面作用。大量研究证明,氧化应激在心力衰竭的发生发展过程中发挥了重要作用。通过探讨氧化应激反应在心力衰竭中的作用机制,为预防及治疗心力衰竭提供新的思路及研究方向。 |
| English Summary: |
| Heart failure(HF)is the end stage of various cardiovascular diseases.In recent years，with the increase in the incidence of cardiovascular diseases such as hypertension and coronary heart disease，the number of people eventually developing into heart failure has gradually increased.Oxidative stress(OS)refers to the imbalance of oxidation and anti-oxidation in the body，leading to inflammatory infiltration of neutrophils，increase of proteases secretion，and production of a large number of oxidative intermediates，which has a negative effect on the body.Huge amount of studies have shown that oxidative stress plays an important role in occurrence and development of heart failure.This paper aims to explore the mechanism of oxidative stress in heart failure and provide new ideas and research directions for prophylaxis and treatment of heart failure. |
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