| 引用本文:宋新梅1，马晓勇2，曹磊1，吴煜龙1，郭志学1，王颖1.补中益气汤联合不同营养方式对肝癌切除术后大鼠免疫功能的影响[J].世界中医药,2019,(11):. |
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| 补中益气汤联合不同营养方式对肝癌切除术后大鼠免疫功能的影响 |
| Effects of Buzhong Yiqi Decoction Combined with Different Nutritional Methods on Immune Function in Rats after Hepatectomy |
| 投稿时间：2018-12-29 |
| DOI：10.3969/j.issn.1673-7202.2019.11.016 |
| 中文关键词: 肝硬化 肝癌切除术 动物模型 不同营养方式 补中益气汤 营养状况 免疫 机制 |
| English Keywords:Liver cirrhosis Hepatectomy Animal model Different nutritional methods Buzhong Yiqi Decoction Nutritional status Immunity Mechanism |
| 基金项目:河北省卫生厅科研基金项目(07269) |
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| 中文摘要: |
| 目的：观察补中益气汤联合不同营养方式对肝癌切除术后大鼠免疫功能的影响。方法：选取45只成功复制肝硬化肝癌并成功用Higgins法行肝部分切除术的大鼠，随机分为常规组、中西结合A组及中西结合B组，每组15只，其中常规组大鼠接受经口进食，中西结合A组采用补中益气汤+肠外营养，中西结合B组采用补充益气汤+肠内营养，连续干预10 d，比较3组大鼠营养指标如血红蛋白（Hb）、总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白LDL）以及免疫指标如CD3+、CD4+、CD8+、IgG、IgM、IgA表达差异。结果：1）3组大鼠Hb、TC、TG、LDL水平低于正常值，3组中中西结合组高于常规组，其中中西医结合B组较A组升高（P<0.05）。2)3组大鼠治疗前CD3+、CD4+、CD4+/CD8+、IgG、IgM、IgA、IL-4、IL-6、TNF-ɑ比较，差异无统计学意义（P>0.05），干预后3组以上指标较治疗前均显著降低,差异有统计学意义（P<0.05），中西结合组低于高于常规组，其中中西医结合B组较A组升高,差异有统计学意义（P<0.05），干预后3组CD8+较治疗前显著升高,差异有统计学意义（P<0.05），中西结合组低于高于常规组，其中中西医结合B组较A组降低,差异有统计学意义（P<0.05）。结论：补中益气汤联合肠内营养既可改善肝硬化肝癌术后的营养状况，又可提升其免疫功能。 |
| English Summary: |
| To observe effects of Buzhong Yiqi Decoction combined with different nutritional methods on immune function in rats after hepatectomy.Methods:Forty-five rats with successfully duplicated cirrhotic hepatoma and successful hepatectomy by Higgins method were included in the study.They were randomly divided into routine group，integrated Chinese and western group A and integrated Chinese and western group B，with 15 rats in each group.The routine group received oral feeding，the integrated Chinese and western group A was used Buzhong Yiqi Decoction+ parenteral nutrition，and the integrated Chinese and western group B was treated with Buzhong Yiqi Decoction+ enteral nutrition.They were intervened continuously for 10 d.Expression differences of nutritional indexes［hemoglobin(Hb)，total cholesterol(TC)，triglyceride(TG)and low density lipoprotein(LDL)］and immune indexes(CD3+，CD4+，CD8+，IgG，IgM and IgA)were compared among the groups.Results:1)The levels of Hb，TC，TG and LDL in the 3 groups were lower than the normal values.Among the 3 groups，those in the integrated Chinese and western groups were higher than those in the routine group，and those in the integrated Chinese and western group B were higher than those in the group A(P<0.05).2)There was no significant difference in the CD3+，CD4+，CD4+/CD8+，IgG，IgM，IgA，IL-4，IL-6 and TNF-α among the 3 groups before the treatment(P>0.05).After the intervention，the above indicators in the 3 groups were significantly lower than those before the treatment(P<0.05).Those in the integrated Chinese and western groups were lower than those in the routine group，and those in the integrated Chinese and western group B were higher than those in the group A(P<0.05).After the intervention，the CD8+ in the 3 groups was increased significantly compared with that before the treatment(P<0.05).That in the integrated Chinese and western groups was lower than that in the routine group，and that in the integrated Chinese and western group B was lower than that in the group A(P<0.05).Conclusion:Buzhong Yiqi Decoction combined with enteral nutrition can improve nutritional status and immune function of cirrhotic hepatoma patients after operation. |
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