| 引用本文:刘亚梅1，徐江1，李晓芸2.养脑通络汤联合氯吡格雷对缺血性脑卒中患者神经功能的影响及机制分析[J].世界中医药,2019,(12):. |
|
| 养脑通络汤联合氯吡格雷对缺血性脑卒中患者神经功能的影响及机制分析 |
| Effects of Yangnao Tongluo Decoction and Clopidogrel on Neurological Function in Patients with Ischemic Stroke and Its Mechanisms |
| 投稿时间：2019-01-29 |
| DOI：10.3969/j.issn.1673-7202.2019.12.037 |
| 中文关键词: 缺血性脑卒中 养脑通络汤 氯吡格雷 NIJSS 神经功能 炎性反应 氧化应激 药物不良反应 |
| English Keywords:Ischemic stroke Yangnao Tongluo Decoction Clopidogrel NIJSS Neural function Inflammatory reaction Oxidative stress Adverse drug reactions |
| 基金项目:秦皇岛市科技支撑项目(201703A100) |
|
| 摘要点击次数: 525 |
| 全文下载次数: 375 |
| 中文摘要: |
| 目的:探讨养脑通络汤联合氯吡格雷对缺血性脑卒中患者神经功能的影响及可能机制。方法:选取2016年9月至2018年7月秦皇岛市骨科医院收治的缺血性脑卒中患者94例作为研究对象,按照随机数字表法分为对照组和观察组,每组47例。对照组接受氯吡格雷治疗,观察组接受养脑通络汤联合氯吡格雷治疗,持续4周后评估疗效。比较2组患者的美国国立卫生研究院卒中量表(NIJSS)评分值、中医证候积分、血清神经损伤相关指标［神经元特异性醇化酶(NSE)、胶质纤维酸性蛋白(GFAP)、S100B蛋白(S100B)］及炎性反应因子［白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、细胞间黏附分子-1(ICAM-1)、转化生长因子β(TGF-β)］、氧化应激指标［过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GSHPx)、丙二醛(MDA)］含量的差异。结果:治疗后,观察组治疗后NIJSS评分值低于对照组;头痛、口舌歪斜、言语謇涩、肢体疼痛、气短乏力的评分值低于对照组;血清中NSE、GFAP、S100B的含量低于对照组(P<0.05)。观察组血清中IL-1β、IL-6、ICAM-1的含量低于对照组,TGF-β的含量高于对照组;CAT、GSHPx的含量高于对照组,MDA的含量低于对照组(P<0.05)。2组患者药物不良反应发生率间的差异无统计学意义(P>0.05)。结论:养脑通络汤可减轻缺血性脑卒中患者的神经功能缺损,机制可能与其减轻机体炎性反应应激反应相关。 |
| English Summary: |
| To investigate the effects of Yangnao Tongluo Decoction combined with clopidogrel on neurological function in patients with ischemic stroke and its possible mechanism.Methods:A total of 94 cases of ischemic stroke patients treated in Qinhuangdao Orthopedics Hospital during September 2016 to July 2018 were randomly divided into a control group and an observation group, with 47 cases in each group.Patients in control group were treated with clopidogrel and those in the observation group were treated with Yangnao Tongluo Decoction and clopidogrel.The efficacy was evaluated after 4 weeks.The NIJSS score, TCM syndromes score, serum neuronal injury related indicators ［Neuron Specific Alcoholase(NSE), Glial Fibrillary Acidic Protein(GFAP), S100B Protein(S100B)］ and inflammatory factors ［Interleukin-1 beta(IL-1 beta), interleukin-6(IL-6), intercellular adhesion molecule-1(ICAM-1), transforming growth factor beta(TGF-beta)］, indicators of oxidative stress ［catalase(CAT), glutathione peroxidase(GSHPx), malondialdehyde(MDA)］ were compared between the 2 groups.Results:After treatment, the NIJSS score of the observation group was lower than that of control group; scores of headache, tongue deviation, speech astringency, limb pain, shortness of breath and fatigue were lower than those of control group; serum contents of NSE, GFAP and S100B were lower than those of control group(P<0.05).Serum contents of IL-1β, IL-6 and ICAM-1 in the observation group were lower than those in control group, and TGF-β was higher than that in control group; serum contents of CAT and GSHPx were higher than those in control group, and the contents of MDA were lower than those in control group(P<0.05).There were no significant difference in the incidence of adverse drug reactions between the 2 groups(P>0.05).Conclusion:Yangnao Tongluo Decoction can alleviate the neurological deficit of ischemic stroke patients.The mechanism may be related to its alleviation of inflammatory stress. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
