| 引用本文:董伯岩1，克珠2，卢旭亚3.藏医放血疗法对急性痛风局部及全身炎性因子的影响[J].世界中医药,2020,(03):. |
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| 藏医放血疗法对急性痛风局部及全身炎性因子的影响 |
| Effects of Tibetan Medicine Bloodletting Therapy on Local and Systemic Inflammatory Factors in Acute Gout |
| 投稿时间：2018-11-13 |
| DOI：10.3969/j.issn.1673-7202.2020.03.032 |
| 中文关键词: 藏医 放血疗法 急性痛风 炎性因子 血尿酸 IL-1β TNF-α HIF-1α |
| English Keywords:Tibetan Medicine Bloodletting therapy Acute gout Inflammatory factors Blood uric acid IL-1β TNF-α HIF-1α |
| 基金项目:西藏自治区藏医药管理局2018年度局级课题（2017029）——藏医放血疗法治疗痛风前后对局部及全身血浆炎性反应因子的影响；西藏自治区藏医药管理局2018年度局级课题（JJKT2018012）——三果汤散对藏医放血疗法治疗痛风前后的血液代谢组学影响及机制研究 |
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| 中文摘要: |
| 目的：评价藏医放血疗法对急性痛风局部及全身炎性因子的影响。方法：选取2017年11月至2018年8月昌都市藏医院收治的急性痛风赤巴型患者30例作为研究对象，采取藏医放血疗法治疗，取放血局部最初0 mL，30 mL，60 mL，90 mL时血液各5 mL，同时分别在放血至0 mL，30 mL，60 mL，90 mL时肘正中静脉取血5 mL，检测白细胞（WBC）、C-反应蛋白（CRP）、血尿酸（UA）、白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）和低氧诱导因子-1α（HIF-1α）水平。结果：放血后全身90 mL与0 mL UA比较，差异有统计学意义（P<0.01），90 mL与0 mL WBC、CRP比较，差异无统计学意义（P>0.05）。放血后全身90 mL与0 mL HIF-1α值比较，差异有统计学意义（P<0.01），90 mL与0 mL IL-1β、TNF-α值，差异无统计学意义（P>0.05）。放血后局部90 mL与0 mL IL-1β、TNF-α、HIF-1α水平比较，差异有统计学意义（P<0.01）。HIF-1α与IL-1β和TNF-α两者呈弱相关。结论：放血疗法通过改善局部组织缺氧，减少局部UA水平，进而导致局部IL-1β、TNF-α、HIF-1α下降，最终起到缓解急性痛风症状的作用。 |
| English Summary: |
| To evaluate effects of Tibetan medicine bloodletting therapy on local and systemic inflammatory factors in acute gout.Methods:A total of 30 cases of acute gout admitted in Changdu Hospital of Tibetan Medicine from November 2017 to August 2018 were selected as study objects and treated with Tibetan medicine bloodletting therapy.In the local, 5 mL blood was taken when bloodletting 0 mL, 30 mL, 60 mL and 90 mL.And 5 mL blood was taken from the median cubital vein when bloodletting 0 mL, 30 mL, 60 mL and 90 mL.WBC, CRP, blood UA, IL-1β, TNF-α and HIF-1α levels were tested.Results:There was statistical difference between the systemic 90 mL and 0 mL UA after the bloodletting(P<0.01), while there was no significant difference between the 90 mL and 0 mL WBC and CRP(P>0.05).There was statistically significant difference between the systematic 90 mL and 0 mL HIF-1α levels after the bloodletting(P<0.01), while there was no significant difference between the 90 mL and 0 mL IL-1β and TNF-α levels(P>0.05).There was statistical difference between the local 90 mL and 0 mL IL-1β, TNF-α and HIF-1α levels after the bloodletting(P<0.01).HIF-1α was weakly correlated with both IL-1β and TNF-α.Conclusion:Bloodletting therapy can improve local tissue hypoxia and reduce local UA level, which leads to a decrease of IL-1β, TNF-α and HIF-1α, and finally relieves symptoms of acute gout. |
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