| 引用本文:刘嘉1，严宝飞1，曾明月2，曾庆琪1,3，杨海军1，张景正1.黄芩-金银花药对治疗新型冠状病毒肺炎潜在作用机制的网络药理学研究[J].世界中医药,2020,(04):. |
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| 黄芩-金银花药对治疗新型冠状病毒肺炎潜在作用机制的网络药理学研究 |
| Potential Mechanism of Couplet Medicines Baical Skullcap Root-Honeysuckle for Coronavirus Disease 2019 Based on Network Pharmacology |
| 投稿时间：2020-02-21 |
| DOI：10.3969/j.issn.1673-7202.2020.04.006 |
| 中文关键词: 黄芩-金银花 药对 新型冠状病毒肺炎 网络药理学 潜在作用机制 |
| English Keywords:Baical Skullcap Root-Honeysuckle Couplet Medicines Coronavirus Disease 2019 Networkpharmacology Potential Mechanism |
| 基金项目:江苏省自然科学基金项目(BK20191498);江苏省高校青蓝工程项目(苏教师[2017]15号);2019年江苏省地方标准项目计划项目(苏市监标[2019]89号);江苏卫生健康职业学院校级课题重大项目(JKA201903) |
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| 中文摘要: |
| 目的:基于网络药理学探讨黄芩-金银花药对与新型冠状病毒肺炎(COVID-19)关联关系及潜在作用机制。方法:利用TCMSP和STRING数据库平台过滤黄芩-金银花的有效化合物及对应作用靶点;运用Cytoscape 3.7.0统计软件建立并分析黄芩-金银花有效化合物-作用靶点网络;利用STRING数据库平台和Cytoscape 3.7.0统计软件建立并分析黄芩-金银花有效化合物作用靶点PPI网络;利用Bioconductor对作用靶点进行GO功能和KEGG通路富集分析。结果:黄芩-金银花59个有效化合物通过171条通路作用于202个靶点发挥其中医临床功效及潜在的COVID-19治疗作用。结论:黄芩-金银花所含的活性化合物可能通过抗病毒、抗炎等和肺、肝及心血管保护等作用,对COVID-19引发的肺损伤、肝损伤、心血管疾病和炎性反应具有潜在的预防与治疗作用,研究结果可为中医药治疗新冠肺炎提供一定的理论基础与科学依据。 |
| English Summary: |
| To investigate the relationship and potential mechanism of couplet medicines baical skullcap root-honeysuckle for Coronavirus Disease 2019(COVID-19) based on network pharmacology. Methods:TCMSP and STRING database were used to filter the effective components and corresponding targets of baical skullcap root-honeysuckle; Cytoscape 3.7.0 software was used to establish and analyze the effective component-target network of baical skullcap root-honeysuckle; STRING database and Cytoscape 3.7.0 software were used to establish and analyze the effective component-target PPI network; Bioconductor was used to analyze the GO function and KEGG pathway enrichment of the targets. Results:In order to produce the TCM efficacy and play a potential role for the treatment of COVID-19, 59 effective functional compounds of baical skullcap root-honeysuckle exerted its effect on 202 targets through 171 pathways. Conclusion:The effective compounds of baical skullcap root-honeysuckle could be antiviral and anti-inflammatory, and have lung, liver and cardiovascular protective effects that could have potential correlation,prevention and treatment effect on lung injury, liver injury, cardiovascular disease and inflammation caused by COVID-19. The research results can provide certain theoretical basis and scientific evidence for the treatment of NCP by TCM. |
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