世界中医药
文章摘要
引用本文:陈红,王小超,陶丽菊,谭军华.雷公藤多苷联合泼尼松治疗类风湿关节炎肺间质病变的临床疗效[J].世界中医药,2020,(04):.  
雷公藤多苷联合泼尼松治疗类风湿关节炎肺间质病变的临床疗效
Analysis of Clinical Efficacy of Tripterygium Wilfordii Glycosides Combined with Prednisone in the Treatment of Rheumatoid Arthritis with Interstitial Lung Disease
投稿时间:2019-07-06  
DOI:10.3969/j.issn.1673-7202.2020.04.023
中文关键词:  雷公藤多苷  泼尼松  类风湿关节炎  肺间质病变  疗效  不良反应  机制  基质金属蛋白酶
English Keywords:Tripterygium glycosides  Prednisone  Rheumatoid arthritis  Interstitial lung disease  Curative effects  Adverse reactions  Mechanism  MMPs
基金项目:国家自然科学基金项目(81860021);广西省自然基金科技计划项目(2014GXNSFAA118251)
作者单位
陈红,王小超,陶丽菊,谭军华 右江民族医学院附属医院风湿免疫科百色533000 
摘要点击次数: 416
全文下载次数: 0
中文摘要:
      目的:探讨雷公藤多苷治疗类风湿关节炎(RA)肺间质病变(ILD)的临床疗效分析。方法:选取2013年12月至2016年12月右江民族医学院附属医院收治的RA-ILD患者100例作为研究对象,按照随机数字表法分为对照组和观察组,每组50例,对照组给予泼尼松治疗,观察组在此基础上给予雷公藤多苷治疗。比较2组患者临床治疗有效率、治疗前后症状评分、红细胞沉降率(ESR)、C反应蛋白(CRP)、类风湿因子(RF)水平、肺高分辨CT(HRCT)积分、用力肺活量(FVC)、第一秒钟用力呼气容积(FEV1)、FEV1/FVC、外周血基质金属蛋白酶1(MMP-1)、基质金属蛋白酶-9(MMP-9)水平变化以及不良反应的差异。结果:雷公藤多苷可明显减少RA-ILD患者的症状评分,提高临床治疗有效率,下降ESR、CRP、RF、HRCT、MMP-9水平,上调FVC、FEV1、FEV1/FVC、MMP-1。观察组和对照组不良反应发生率差异无统计学意义(P>0.05)。结论:雷公藤多苷可有效治疗RA-ILD,其作用机制可能通过MMPs介导。
English Summary:
      To explore the clinical efficacy of Tripterygium wilfordii polyglycosides in the treatment of rheumatoid arthritis(RA)pulmonary interstitial lesion(ILD).Methods:A total of 100 patients with RA-ILD were randomly divided into a control group and a study group,with 50 cases in each group.The control group was treated with prednisone and the study group was treated with Tripterygium wilfordii polyglycosides based on the control group.The total clinical effective rate,symptom scores,erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),rheumatoid factor(RF),lung high resolution CT(HRCT)score,forced vital capacity(FVC),forced expiratory volume in 1s(FEV1),FEV1/FVC,matrix metalloproteinase-1(MMP-1)and matrix metalloproteinase-9(MMP-9)levels in peripheral blood and adverse reactions were compared between the 2 groups before and after treatment.Results:Tripterygium wilfordii polyglycosides could significantly reduce the TCM syndrome scores of RA-ILD patients,increase the total clinical effective rate,decrease the levels of ESR,CRP,RF,HRCT and MMP-9,and up-regulate FVC,FEV1,FEV1/FVC and MMP-1.There was no significant difference in the incidence of adverse reactions between the study group and control group(P > 0.05).Conclusion:Tripterygium wilfordii polyglycosides can effectively treat RA-ILD,and its mechanism may be mediated by MMPs,which is worthy of further clinical promotion.
查看全文  查看/发表评论  下载PDF阅读器