| 引用本文:吴丹，王晓滨，丛慧芳，刘树民，梁宇.针灸对肥胖型多囊卵巢综合征患者卵巢功能的影响[J].世界中医药,2020,(16):. |
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| 针灸对肥胖型多囊卵巢综合征患者卵巢功能的影响 |
| Effects of Acupuncture on the Ovarian Function in Obese Patients with Polycystic Ovary Syndrome |
| 投稿时间：2020-06-09 |
| DOI：10.3969/j.issn.1673-7202.2020.16.028 |
| 中文关键词: 针灸 肥胖 多囊卵巢综合征 卵巢功能 瘦素 黄体生成素 卵泡刺激素 雌二醇 睾酮 |
| English Keywords:Acupuncture Obese Polycystic ovary syndrome Ovarian function Leptin Luteinizing hormone Follicle stimulating hormone Estradiol Testosterone |
| 基金项目:黑龙江省卫生计生委科研课题（2018327） |
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| 中文摘要: |
| 目的：探讨针灸对肥胖型多囊卵巢综合征（PCOS）患者卵巢功能的影响。方法：选取2015年3月至2018年4月黑龙江中医药大学附属第二医院收治的肥胖型PCOS患者112例作为研究对象，按照随机数字表法随机分为对照组和观察组，每组56例。对照组采用二甲双胍治疗，观察组在对照组基础上给予针灸治疗，2组均治疗3个月经周期。比较2组患者治疗前后卵巢功能、体质量指数（BMI）、血清性激素及血清瘦素（LEP）水平，记录2组不良反应发生情况。结果：与治疗前比较，治疗后2组患者卵巢体积（OV）均明显缩小，卵泡数目及BMI均明显减少，且观察组均明显小于/少于对照组，差异有统计学意义（P<0.05）。与治疗前比较，治疗后2组患者LEP、黄体生成素（LH）、卵泡刺激素（FSH）、雌二醇（E2）及睾酮（T）水平及LH/FSH均明显降低，且观察组低于对照组，差异有统计学意义（P<0.05）；2组患者血清E2水平均明显升高，且观察组高于对照组，差异有统计学意义（P<0.05）。观察组不良反应发生率（5.36%）明显低于对照组（16.07%），差异有统计学意义（P<0.05）。结论：针灸可有效调节肥胖型PCOS患者血清性激素水平，降低血清LEP水平及肥胖程度，改善患者卵巢功能，且效果优于单纯西药治疗，安全性高。 |
| English Summary: |
| To explore the effects of acupuncture on the ovarian function in obese patients with polycystic ovary syndrome(PCOS).Methods:A total of 112 cases patients with obese PCOS who were treated in the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine from March 2015 to April 2018 were selected as the research objects and were divided into a control group and an observation group，with 56 cases in each group.The control group was treated with metformin，while the observation group was treated with acupuncture on the basis of the control group.The 2 groups were treated for 3 menstrual cycles.The ovarian function，BMI，the levels of serum sex hormones and LEP level of the 2 groups were compared before and after treatment in the 2 groups，the occurrence situation of the adverse reactions in the 2 groups were recorded.Results:Compared with those before treatment，the OV significantly reduced after treatment in the 2 groups，the number of follicles and BMI significantly decreased(P<0.05 or P<0.01)，and the observation group was significantly lower than the control group(P<0.05 or P<0.01).Compared with those before treatment，the levels of serum LEP，LH，FSH，T and LH/FSH significantly decreased，and the observation group was significantly lower than the control group(P<0.05 or P<0.01); the levels of serum E2 significantlyincreased in the 2 groups，and the observation group was significantly higher than that of the control group(P<0.01).The incidence of total adverse reactions in the observation group was 5.36%，which was significantly lower than that in the control group(16.07%)(P<0.05).Conclusion:Acupuncture can effectively regulate the levels of serum sex hormone in obese PCOS patients，reduce the level of serum LEP and degree of obesity，and improve ovarian function.The effects are better than Western medicine alone，with high safety. |
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