| 引用本文:郭银雪，葛平玉，胡茂蓉.肾茶黄酮通过ERK/CT-1通路治疗急性肾衰模型鼠氧化应激的实验研究[J].世界中医药,2020,(18):. |
|
| 肾茶黄酮通过ERK/CT-1通路治疗急性肾衰模型鼠氧化应激的实验研究 |
| Effects of Kidney Tea Flavonoids on Oxidative Stress in Rats with Acute Renal Failure Through ERK/CT-1 Pathway |
| 投稿时间：2019-10-10 |
| DOI：10.3969/j.issn.1673-7202.2020.18.006 |
| 中文关键词: 急性肾衰 模型鼠 氧化应激 MDA SOD ERK CT-1 |
| English Keywords:Acute renal failure Model mice Oxidative stress Malondialdehyde Superoxide dismutase ERK CT-1 |
| 基金项目:贵州省科技厅科学技术联合资金项目（黔科合LH字【2014】7346号）——肾茶黄酮对急性肾衰中肾小管上皮细胞保护作用的研究；贵州省科技厅科学技术联合资金项目（黔科合LH字【2016】7519号）——化痰祛瘀法通过保护血管内皮功能改善高尿酸血症患者勃起功能的临床观察 |
|
| 摘要点击次数: 727 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的：观察肾茶黄酮对急性肾衰（Acute Renal Failure，ARF）模型鼠氧化应激水平的干预效应，同时观察其对ERK/CT-1通路的影响。方法：将36只急性肾衰模型大鼠随机分为模型组和肾茶黄酮观察组，每组18只，另设假手术组18只。连续肾茶黄酮干预7 d后比较各组大鼠肝肾功能、丙二醛(MDA)含量及超氧化物歧化酶(SOD)活性、肾组织ERK、p-ERK、CT-1水平的变化。结果：肾茶黄酮可明显降低ARF模型鼠肾质量、肾质量/体质量，改善大鼠肝大和鼠蛋白尿、血浆肌酐、尿素氮水平，减少MDA含量，上调SOD活性，增加肾组织p-ERK、CT-1水平。结论：肾茶对急性肾衰有明显治疗作用，可能通过ERK/CT-1通路介导肾保护效应。 |
| English Summary: |
| To observe the intervention effects of kidney tea flavonoids on oxidative stress in rats with acute renal failure(ARF)and its effect on ERK/CT-1 pathway.Methods:A total of 36 rats with acute renal failure were randomly divided into a model group(n=18)，and a kidney tea flavonoid treatment group(n=18)and a sham operation group(n=18).The changes of liver and kidney function，malondialdehyde(MDA)content，superoxide dismutase(SOD)activity，renal tissue ERK，p-ERK and CT-1 levels were compared after continuous kidney tea flavonoids intervention for 7 days.Results:Kidney tea flavonoids could significantly reduce the kidney weight and kidney weight/body weight of ARF model rats，improve the levels of proteinuria，plasma creatinine and urea nitrogen，reduce the content of MDA，increase the activity of SOD and increase the levels of p-ERK and CT-1 in renal tissue.Conclusion:Kidney tea has obvious therapeutic effects on acute renal failure，which may be mediated by ERK/CT-1 pathway. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
