| 引用本文:顾任钧1，李子赟2，李鹏飞3，张春兵1，3.川芎嗪注射液对急性缺血性脑卒中疗效与安全性的Meta分析[J].世界中医药,2020,(19):. |
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| 川芎嗪注射液对急性缺血性脑卒中疗效与安全性的Meta分析 |
| Meta-analysis of Efficacy and Safety of Ligustrazine Injection on Acute Ischemic Stroke |
| 投稿时间：2020-05-09 |
| DOI：10.3969/j.issn.1673-7202.2020.19.012 |
| 中文关键词: 川芎嗪注射液 缺血性脑卒中 随机对照实验 系统评价 Meta分析 |
| English Keywords:Ligustrazine Injection Ischemic stroke Randomized controlled trial Systematic review Meta-analysis |
| 基金项目:江苏省“333工程第二层次人才”培养项目(BRA2018088) |
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| 中文摘要: |
| 目的:系统评价川芎嗪注射液治疗急性缺血性脑卒中的疗效与安全性。方法:计算机检PubMed,Cochrane,Embase,Medline,Web of Science,中国知网,万方数据库,维普数据库和中国生物医学文献数据库。检索时限均为从建库至2020年3月1日。检索对象为所有川芎嗪注射液治疗急性缺血性脑卒中患者的临床随机对照实验文献。根据Cochrane系统评价手册对纳入文献的质量进行评价,采用RevMan5.2进行Meta分析。结果:纳入以有效率、神经功能缺损评分、血液流变学指标为评价标准的文献共21篇,观察组病例1 084例,对照组病例1 055例。Meta分析结果显示,有效率RR=1.19,95%CI［1.14,1.24］;神经功能缺损评分WMD=-3.62,95%CI［-4.41,-2.84］;血液流变学指标中,全血低切黏度WMD=-1.37,95%CI［-1.73,-1.01］;全血高切黏度WMD=-0.73,95%CI［-0.91,-0.55］;红细胞压积WMD=-4.36,95%CI［-6.93,-1.78］;纤维蛋白原WMD=-0.49,95%CI［-0.77,-0.21］;红细胞聚集指数WMD=-0.57,95%CI［-0.81,-0.34］;不良事件RR=0.83，95%CI［0.36，1.90］。结论:现有的临床证据表明,川芎嗪注射液对急性缺血性脑卒中患者有较好的治疗作用,对改善其血液流变学指标有一定的作用，川芎嗪注射液是一种相对安全的中药制剂。 |
| English Summary: |
| To evaluate the efficacy and safety of Ligustrazine Injection on acute ischemic stroke. Methods:Database of PubMed, Cochrane,Embase,Medline,Web of Science, CNKI, Wanfang, VIP and SinoMed were searched. The retrieval time were from the establishment of the database to 1st March 2020. The retrieval object was all the clinical randomized controlled trials literature of ligustrazine Injection in the treatment of patients with acute ischemic stroke. According to the Cochrane systematic review manual, the quality of the included literature was evaluated, and RevMan5.2 was used for Meta analysis. Results:A total of 21 papers based on effective rate, neurological deficit score, and hemorheological indicators were included. There were 1 084 cases in the observation group and 1 055 cases in the control group. Meta analysis results showed that the effective rate RR=1.19, 95%CI ［1.14, 1.24］; neurological deficit score WMD=-3.62, 95%CI ［-4.41,-2.84］; among the hemorheology indexes, whole blood is low shear viscosity WMD=-1.37,95%CI［-1.73,-1.01］; whole blood high shear viscosity WMD=-0.73,95%CI［-0.91,-0.55］; Hematocrit WMD=-4.36,95%CI ［-6.93,-1.78］; fibrinogen WMD=-0.49,95%CI［-0.77,-0.21］; red blood cell aggregation index WMD=-0.57,95%CI［-0.81,-0.34］; adverse events RR=0.83, 95% CI ［0.36, 1.90］. Conclusion:The existing clinical evidence suggests that ligustrazine injection is effective on acute ischemic stroke and improving hemorheology index. Ligustrazine injection is a relatively safe traditional Chinese medicine preparation. |
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