| 引用本文:周雪，乐娜，王玉杰，瞿研，汤如莹，王林元，张建军.阿萨伊及其醇提物对虚热及虚寒证小鼠甲状腺素及代谢水平的影响[J].世界中医药,2020,(01):. |
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| 阿萨伊及其醇提物对虚热及虚寒证小鼠甲状腺素及代谢水平的影响 |
| Effects of ANai Alcohol Extract on Thyroxine and Metabolic Level of Deficiency-Heat and Deficiency-Cold Syndrome in Mice |
| 投稿时间：2019-04-12 |
| DOI：10.3969/j.issn.1673-7202.2020.01.009 |
| 中文关键词: 阿萨伊 阿萨伊醇提物 环核苷酸 温度趋向性 甲状腺素 代谢水平 物质基础 |
| English Keywords:Acaí Acaí alcohol extract Cyclic nucleotides Temperature tendency Thyroxine Metabolic level Material basis |
| 基金项目:国家自然科学基金项目（81173569）；北京中医药大学中青年教师自主课题（2018-JYBZZ-JS028、2016-JYB-JSPY-013）；北京中医药大学在读研究生项目（2015-JYB-XS002） |
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| 中文摘要: |
| 目的：通过考察阿萨伊醇提物对虚热及虚寒证小鼠的温度趋向性、环核苷酸、甲状腺素及代谢水平的影响，探讨阿萨伊寒凉药性的物质基础。方法：将昆明种雄性小鼠随机分为空白组、虚热模型组、虚热+阿萨伊冻干原粉组、虚热+阿萨伊醇提物组、虚寒模型组、虚寒+肉桂组、虚寒+阿萨伊冻干原粉组、虚寒+阿萨伊醇提物组。虚热模型组小鼠每天下午灌胃给予甲状腺片溶液160 mg/kg，虚寒模型组小鼠给予氢化可的松溶液25 mg/kg，连续14 d，各给药组灌胃相应药物，实验结束后测定相关指标。结果：阿萨伊醇提物与寒凉性质的阿萨伊作用类似，与温热性质的肉桂作用相反，对虚热模型小鼠作用比较明显，而对虚寒模型无明显改善作用。结论：该实验采用同类比较，异类反证的方法，通过测定动物温度趋向性、环核苷酸、甲状腺激素与能量代谢水平等相关指标的含量变化，证明了阿萨伊醇提物为阿萨伊寒凉药性的物质基础。 |
| English Summary: |
| To investigate the temperature tendency, cyclic nucleotides, thyroxine and metabolic level of Acaí alcohol extract on deficiency-heat and deficiency-cold models and to clarify the material basis of the cool drug properties of the Acaí.Methods:KM mice were randomly divided into a blank group, a deficiency-heat model group, a deficiency-heat+Acaí group, a deficiency-heat+Acaí alcohol extract group, a deficiency-cold model group, a deficiency-cold+Cortex Cinnamomi group, a deficiency-cold+Acaí group, a deficiency-cold+Acaí alcohol extract group.The mice were administered orally at the dose of 160 mg/kg thyroxine and 25 mg/kg hydrocortisone on the afternoon from the first day per day respectively for 14 days to induce deficiency-heat and deficiency-cold models.Each administration group was given the corresponding drug.At the end of the experiment, the related indexes were determined.Results:Acaí alcohol extract had the same effect with Acaí on deficiency-heat model.In contrast to Cortex Cinnamomi, there was no significant effect on the deficiency-cold model.Conclusion:In this study, the content changes of temperature tendency, cyclic nucleotide, thyroid hormone, metabolism and other related indicators were preliminarily determined to prove that the alcohol extract of Acaí is the material basis of Acaí cold medicine by the methods of homogeneous comparison and heterogeneous disproval. |
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