| 引用本文:陈与丰1，陈建新1，王雅蕾1，刘晓庆2，侯晓莹2，赵赫2，何玉瑶2，董云芳2，钟利群2，谭琰1.泽泻汤治疗梅尼埃病作用机制的网络药理学探讨[J].世界中医药,2021,(07):. |
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| 泽泻汤治疗梅尼埃病作用机制的网络药理学探讨 |
| Network Pharmacological Study on the Mechanism of Zexie Decoction in the Treatment of Meniere Disease |
| 投稿时间：2020-12-01 |
| DOI：10.3969/j.issn.1673-7202.2021.07.008 |
| 中文关键词: 梅尼埃病 糖皮质激素受体 泽泻汤 网络药理学 炎症反应 |
| English Keywords:Meniere Disease Glucocorticoid receptor Zexie Decoction Network pharmacology Inflammation |
| 基金项目:国家重点研发计划“中医药现代化研究”重点专项（2017YFC1703500）——中医药大数据中心与健康云平台构建；国家重点研发计划“中医药现代化研究”重点专项 （2017YFC1703502）——中医临床科研信息共享系统的研发与实施；国家自然科学基金（81904049）；中华中医药学会青年人才托举项目（CACM-2018-QNRC2-C06）；北京中医药大学东直门医院科技创新专项（DZMKJCX-2020-017） |
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| 中文摘要: |
| 目的：通过网络药理学方法探讨泽泻汤治疗梅尼埃病（Meniere Disease，MD）的作用机制。方法：利用SymMap、TCMSP、TCMID、BATMAN-TCM等中医药数据库及TargetNet药物-靶点谱在线计算平台，获取泽泻汤有效成分及作用靶点；通过OMIM、Gene Cards、TTD、CTD等疾病基因数据库，获取MD相关靶标基因；利用STRING蛋白质数据库，构建蛋白质-蛋白质相互作用（PPI）网络；利用Cytoscape信息分析软件，获取关键靶标基因、构建中药-有效成分-靶标基因网络图；利用R软件进行信号通路分析。结果：泽泻汤中69种有效成分可作用于88个MD相关基因，以核受体（如糖皮质激素受体）为主要作用靶点，参与IL-17、肿瘤坏死因子（TNF）相关的核因子κB信号通路介导的炎症反应。结论：由核受体糖皮质激素受体-核因子κB介导的炎症反应通路，可能是泽泻汤减少MD炎症反应，缓解膜迷路水肿的重要作用途径之一。 |
| English Summary: |
| To explore the mechanism of Zexie Decoction in the treatment of Meniere disease(MD) based on network pharmacology.Methods:SymMap,TCMSP,TCMID,BATMAN-TCM and other Chinese medicine databases and TargetNet drug-target spectrum online computing platform were used to obtain the effective ingredients and targets of Zexie Decoction; through OMIM,Gene Cards,TTD,CTD and other disease gene databases,MD-related target genes were obtained; STRING protein database were used to construct a protein interaction network; Cytoscape information analysis software was used to obtain key target genes,a network diagram of traditional Chinese medicine-active ingredients-target genes was constructed; R software was used to analyze signal pathways.Results:A total of 69 active components were screened from Zexie Decoction.These components acted on 88 related targets of MD.It took nuclear receptors (such as glucocorticoid receptors) as the main targets,and participated in the inflammatory response mediated by IL-17 and TNF-related NFκB signaling pathways.Conclusion:The inflammatory response pathway mediated by the nuclear receptor glucocorticoid receptor-NFκB may be one of the important pathways for Zexie Decoction to reduce MD inflammatory response and relieve membrane labyrinth edema. |
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