| 引用本文:侯志涛1,2，宋晓晨1，宋丽颖1，李瑒1，陈晶1，商洪才2.基于网络药理学探讨强心胶囊治疗慢性心力衰竭的作用机制[J].世界中医药,2021,(07):. |
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| 基于网络药理学探讨强心胶囊治疗慢性心力衰竭的作用机制 |
| Discussion on the Mechanism of Qiangxin Capsule in the Treatment of Chronic Heart Failure Based on Internet Pharmacology |
| 投稿时间：2020-07-07 |
| DOI：10.3969/j.issn.1673-7202.2021.07.010 |
| 中文关键词: 强心胶囊 慢性心力衰竭 网络药理学 作用机制 |
| English Keywords:Qiangxin Capsule Chronic heart failure Network pharmacology Mechanism |
| 基金项目:黑龙江省自然科学基金项目（H201485） |
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| 中文摘要: |
| 目的:基于网络药理学分析预测强心胶囊治疗慢性心力衰竭的作用机制。方法:应用中医药系统药理学数据库与分析平台(TCMSP)筛选出强心胶囊所含有效成分和相关靶标蛋白。根据药代动力学ADME参数，以口服生物利用度(OB)≥30%，药物相似性(DL)≥0.18，生物半衰期(HL)≥4.00为条件筛选出活性成分。从数据库Uniprot中获得预测的活性成分作用靶点。通过CTD、TTD、DrugBanK数据库挖掘疾病相关的作用靶点。通过基因注释工具Matescape分析强心胶囊干预慢性心力衰竭的分子机制。结果:获得强心胶囊活性成分108个，作用靶点267个，疾病相关靶点32 730个，最终获得强心胶囊干预心力衰竭关键靶点264个。PPI网络构建筛选出关键靶点47个。富集分析强心胶囊干预慢性心力衰竭的关键靶点主要参与MAPK、HIF-1、TNF、FoxO、PI3K-AKT、促性腺激素、癌症、T细胞受体和钙离子信号通路等。结论:强心胶囊不仅可直接对慢性心力衰竭起到治疗作用，还可通过激素、细胞代谢、炎性机制及免疫因子等间接发挥疗效。 |
| English Summary: |
| To analyze and predict the mechanism of Qiangxin Capsule in the treatment of chronic heart failure based on network pharmacology.Methods:The active ingredients and related target proteins in Qiangxin Capsules were screened by the systematic pharmacology database and analysis platform of traditional Chinese medicine (TCMSP).According to the pharmacokinetic ADME parameters,the active ingredients were screened under the conditions of oral bioavailability (OB) ≥ 30%,drug similarity (DL) ≥ 0.18,and biological half-life (HL) ≥ 4.00.The predicted target of active ingredient were obtained from the database (Uniprot).CTD,TTD,DrugBanK databases were used to explore disease-related targets.The molecular mechanism of Qiangxin Capsule's intervention in chronic heart failure were analyzed through gene annotation tool Matescape.Results:A total of 108 active components,267 action targets and 32,730 disease-related targets of Qiangxin Capsules were obtained,and finally 264 key targets of Qiangxin Capsules for the intervention of heart failure were obtained.The PPI network was constructed and 47 key targets were selected.Enrichment analysis showed that the key target of Qiangxin Capsule intervention in chronic heart failure mainly involved in MAPK signaling,HIF-1 signaling,TNF signaling,FOXO signaling,PI3K-AKT signaling,gonadotropin signaling,cancer signaling,T-cell receptor signaling and calcium signaling,etc.Conclusion:Qiangxin Capsule can not only directly treat chronic heart failure,but also play an indirect role through hormone,cell metabolism,inflammatory mechanism and immune factors. |
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