世界中医药
文章摘要
引用本文:吕玲玲1,2,谢松3,张凯媛1,郑岚1.厚朴饮片标准汤剂的制备及质量标准研究[J].世界中医药,2020,(21):.  
厚朴饮片标准汤剂的制备及质量标准研究
Study on Preparation and Quality Standard of Standard Decoction of Houpo Decoction Pieces
投稿时间:2019-11-26  
DOI:10.3969/j.issn.1673-7202.2020.21.008
中文关键词:  厚朴饮片  标准汤剂  质量标准  制备工艺  厚朴酚
English Keywords:Houpo Decoction pieces  Standard decoction  Quality standard  Preparation process  Magnolol
基金项目:上海市2018杏林信息人才培养计划项目[ZY(2018-2020)-RCPY-3013];上海市名中医沈小珩学术经验研究工作室(SHGZS-2017011)
作者单位
吕玲玲1,2,谢松3,张凯媛1,郑岚1 1 上海交通大学医学院附属瑞金医院,上海,200025
2 上海中医药大学,上海,201203
3 和记黄埔医药(上海)有限公司,上海,201203 
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中文摘要:
      目的:为建立厚朴饮片标准汤剂的制备方法,并进行质量标准研究。方法:采用标准化工艺制备标准汤剂,制备15批次不同产地的厚朴饮片标准汤剂,以厚朴酚和和厚朴酚作为定量检测指标,并进行转移率、出膏率计算及指纹图谱研究,并建立其分析方法。结果:15批次厚朴样品制成的标准汤剂中,厚朴饮片的标准汤剂的出膏率在7.13%~12.60%之间,平均值为10.65%;厚朴酚的转移率在2.75%~4.44%之间,平均值为3.47%;和厚朴酚的转移率在6.09%~9.62%之间,平均值为7.25%。采用软件《中药色谱指纹图谱相似度评价系统》进行厚朴样品的特征图谱进行分析,对15批厚朴饮片及标准汤剂进行相似度评价,其相似度均大于0.9。结论:本研究中的样品处理方法简单易行、重复性好,可用于厚朴标准汤剂的制备及质量标准研究。
English Summary:
      To establish the preparation method of standard decoction of Houpo Decoction pieces and to study the quality standard.Methods:Standard decoction was prepared by standardized process,and 15 batches of standard decoction of Houpo Decoction pieces from different regions were prepared.Magnolol and honokiol were used as quantitative detection indicators,and the transfer rate,paste rate calculation and fingerprint spectrum research were carried out,and the analysis method was established.Results:Among the standard decoctions made from 15 batches of Cortex Magnoliae Officinalis samples,the paste rate of the standard decoction of Cortex Magnoliae Officinalis was 7.13%~12.60%,with an average of 10.65%; the transfer rate of magnolol was 2.75%~4.44%,the average was 3.47%; the transfer rate of Cortex Magnoliae Officinalis was between 6.09%~9.62%,and the average was 7.25%.The software “Chinese Medicine Chromatographic Fingerprint Similarity Evaluation System” was used to analyze the characteristic maps of Cortex Magnoliae Officinalis samples,and 15 batches of Houpo Decoction pieces and standard decoctions were evaluated for similarity.The similarities were all greater than 0.9.Conclusion:The sample treatment method in this study is simple,feasible,which can be used for preparation and quality standard study of Cortex Magnoliae Officinalis standard decoction.
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