| 引用本文:王惠娟1，谭颖子2，鲁翠红1，孟闫燕2.冠心丹参滴丸治疗冠心病心绞痛临床疗效的Meta分析[J].世界中医药,2020,(21):. |
|
| 冠心丹参滴丸治疗冠心病心绞痛临床疗效的Meta分析 |
| Effects of Clinical Effects of Guanxin Danshen Dripping Pills in the Treatment of Patients with Coronary heart Disease Angina Pectoris：Meta-analysis |
| 投稿时间：2019-07-23 |
| DOI：10.3969/j.issn.1673-7202.2020.21.014 |
| 中文关键词: 冠心丹参滴丸 冠心病 系统评价 Meta分析 心血管事件 炎性反应 血液流变学 不良反应 |
| English Keywords:Guanxin Danshen Droping Pills Angina Systematic review Meta-analysis Cardiovascular events Inflammation Hemorheology Adverse reactions |
| 基金项目:国家自然科学基金项目（81303150）;中国中医科学院苗圃课题（ZZ11-066） |
|
| 摘要点击次数: 322 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的：评价冠心丹参滴丸治疗冠心病的有效性。方法：检索Cochrane Library、PubMed、EMBASE、中国期刊全文数据库、中文科技期刊数据库、万方医学数据库、中国生物医学期刊文献数据库等筛选冠心丹参滴丸治疗冠心病的临床研究，时间截止到2019年6月。根据Cochrane手册对纳入文献进行质量评价，使用RevMan 5.3软件进行Meta分析。结果：共纳入22项研究，包含2 137例。Meta分析结果显示，冠心丹参滴丸联合常规西药治疗可进一步降低冠心病患者的心血管事件发生率（P=0.01）；并能改善冠心病患者的心绞痛症状（P<0.000 1）。冠心丹参滴丸联合常规西药治疗还可进一步降低冠心病患者的高敏C反应蛋白（hs-CRP）和细胞白细胞介素-18（IL-18）水平(P<0.000 01，P=0.002)；并可改善血液流变学相关指标(P<0.05)。共有2篇文献报告了不良反应事件，其中冠心丹参滴丸观察组3例，对照组6例，组间差异无统计学意义（P>0.05）。结论：冠心丹参滴丸联合常规西药治疗冠心病，在降低心血管事件、缓解心绞痛症状、降低炎性反应和改善血液流变学指标等方面优于单纯西药治疗，且未增加不良反应发生率，说明冠心丹参滴丸联合常规西药可能是治疗冠心病的有效手段。 |
| English Summary: |
| To evaluate the effects of Guanxin Danshen Dripping Pills in the treatment of patients with coronary heart disease.Methods:Cochrane Library，PubMed，EMBASE，Chinese Journal Full-text Database，Chinese Biomedical Journal Literature Database，etc.were searched to screen the clinical research of Guanxin Danshen Dropping Pills in the treatment of coronary heart disease.The time was up to June 2019.The quality of the included literature was evaluated according to the Cochrane Handbook，and the RevMan 5.3 software was used for Meta analysis.Results:A total of 22 studies involving 2137 patients were included.Meta analysis results showed that Guanxin Danshen Dripping Pills combined with conventional Western medicine treatment can further reduce the incidence of cardiovascular events in patients with coronary heart disease(P=0.01); and can improve the symptoms of angina in patients with coronary heart disease(P<0.000 1).Meanwhile，Guanxin Danshen Dripping Pills combined with conventional Western medicine treatment can further reduce the levels of high-sensitivity C-reactive protein(hs-CRP)and interleukin-18(IL-18)in patients with coronary heart disease(P<0.000 01，P=0.002); it can improve the related indexes of hemorheology(P<0.05).A total of 2 papers reported adverse events，including 3 cases in the Guanxin Danshen Dripping Pill treatment group and 6 cases in the control group.There was no significant difference between the 2 groups(P>0.05).Conclusion:Guanxin Danshen Droping Pills combined with conventional therapy in the treatment of cardiovascular events，is better to the single Western group in reducing the incidence of cardiovascular incident，relieving angina，reducing inflammatory response and improving the state of hemorheology etc.，without increasing the incidence of adverse reactions，suggesting Guanxin Danshen Droping Pills combined with routine Western medicine may be the effective method in the treatment of coronary heart disease. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
