世界中医药
文章摘要
引用本文:陈雁南1,段优2.加味甘草干姜汤联合维生素B12治疗复发性口腔溃疡的临床效果[J].世界中医药,2020,(21):.  
加味甘草干姜汤联合维生素B12治疗复发性口腔溃疡的临床效果
Clinical Efficacy of Modified Gancao Ganjiang Decoction Combined with Vitamin B12 on Recurrent Oral Ulcer
投稿时间:2019-05-14  
DOI:10.3969/j.issn.1673-7202.2020.21.020
中文关键词:  复发性口腔溃疡  加味甘草干姜汤  维生素B12  T淋巴细胞亚群  口腔微环境  复发风险  作用机制  安全性
English Keywords:Recurrent oral ulceration  Modified Gancao Ganjiang Decoction  Vitamin B12  T-lymphocyte subsets  Oral microenvironment  Recurrence risk  Mechanism of action  Safety
基金项目:重庆市人民医院医学科技创新基金项目(Y2017MSXM11)
作者单位
陈雁南1,段优2 1 中国科学院大学重庆医院/重庆市人民医院重庆400013 2 重庆市巴南区人民医院重庆401320 
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中文摘要:
      目的:探讨加味甘草干姜汤联合维生素B12治疗复发性口腔溃疡(ROU)的临床效果。方法:选取2016年8月至2018年8月重庆市人民医院收治的ROU患者124例作为研究对象,随机分成观察组和对照组,每组62例。对照组口服维生素B12治疗,观察组在此基础上内服加味甘草干姜汤治疗,疗程均为14 d。比较2组疗效及安全性。结果:观察组总有效率达96.8%(60/62),显著高于对照组85.5%(53/62),差异有统计学意义(P<0.05)。与治疗前比较,2组治疗后疼痛指数、溃疡面积和平均溃疡期均显著改善,差异有统计学意义(P<0.05),外周血CD3+、CD4+水平和CD4+/CD8+比值及唾液中链球菌、韦荣菌数量均显著上升,差异有统计学意义(P<0.05),外周血CD8+水平均显著下降,差异有统计学意义(P<0.05);且观察组比对照组对以上指标的改善更显著,差异有统计学意义(P<0.05)。2组均未见明显不良反应。随访6个月,观察组复发率为11.3%(7/62),较对照组的25.8%(16/62)显著降低,差异有统计学意义(P<0.05)。结论:加味甘草干姜汤联合维生素B12治疗ROU的整体疗效确切,可能与其显著纠正外周血T淋巴细胞亚群免疫失衡、维持口腔微环境稳态有关。
English Summary:
      To explore the clinical efficacy of modified Gancao Ganjiang Decoction combined with Vitamin B12(VB12)on recurrent oral ulceration(ROU).Methods:A total of 124 ROU patients admitted to Chongqing General Hospital from August 2016 to August 2018 were selected as the research objects and were divided into an observation group and a control group,with 62 cases in each group,according to random number table.The control group was administrated orally with VB12,while the observation group was treated with Jiawei Gancao Ganjiang Decoction plus VB12.All patients were treated for 14 days.The clinical efficacy and safety between the 2 groups were compared.Results:The overall effective rate of the observation group reached 96.8%(60/62),much higher than 85.5%(53/62)of the control group(P<0.05).Compared with those before treatment,the pain index,ulcer area and average ulcer period were significantly improved in the 2 groups after treatment(P<0.05),peripheral blood CD3+,CD4+ levels,CD4+/CD8+ ratio,and the number of streptococcus and veillonella in saliva increased significantly(P<0.05),peripheral blood CD8+ level decreased significantly(P<0.05); and the observation group improved more significantly than the control group in indicators(P<0.05).There were no obvious side effects in both groups.Follow-up for 6 months,the recurrence rate of the observation group was 11.3%(7/62)significantly lower than that of the control group [25.8%(16/62)](P<0.05).Conclusion:The overall curative effect of Jiawei Gancaoganjiang Decoction combined with VB12 in the treatment of ROU is definite and may be related to its significantly correction of the immune imbalance of peripheral blood T lymphocyte subsets and maintaining the homeostasis of the oral microenvironment.
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