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文章摘要
引用本文:任宇哲1，于宙1，陈宏2，杨泽一3，杨祥正1.芥子防哮膏穴位贴敷联合平喘方治疗小儿哮喘的临床效果[J].世界中医药,2020,(21):.  
芥子防哮膏穴位贴敷联合平喘方治疗小儿哮喘的临床效果
Clinical Study of Mustard Antiasthmatic Ointment Acupoint Application Combined with Pingchuan Prescription in the Treatment of Childhood Asthma
投稿时间：2019-08-25  
DOI：10.3969/j.issn.1673-7202.2020.21.024
中文关键词:  小儿哮喘  芥子防哮膏穴位贴敷  平喘方  中医证候积分  肺功能  外周血嗜酸性粒细胞  白细胞介素-17  临床研究
English Keywords:Pediatric asthma  Mustard Antiasthmatic Ointment Acupoint Application  Pingchuan Formula  Traditional Chinese medicine syndrome  Lung function  Peripheral blood eosinophils  Interleukin-17  Clinical research
基金项目:黑龙江省自然基金面上项目（H2018052）
作者单位
任宇哲1，于宙1，陈宏2，杨泽一3，杨祥正1 1 北京中医药大学深圳医院（龙岗），深圳，518100； 2 黑龙江中医药大学附属第一医院，哈尔滨，150040； 3 北京中医药大学，北京，100029 
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中文摘要:
      目的：研究芥子防哮膏穴位贴敷联合平喘方治疗小儿哮喘的临床疗效。方法：选取2017年7月至2018年9月黑龙江中医药大学附属第一医院收治的小儿哮喘患者40例作为研究对象，按照随机分类方法分为对照组与观察组，每组20例。其中对照组给予常规对症治疗，观察组在对照组的基础上加用穴位贴敷芥子防哮膏联合平喘方治疗，连续治疗4周后观察临床疗效，比较2组患儿治疗前后中医证候积分、第1秒钟用力呼气量（FEV1）、最大呼气流速（PEF）、肺活量（FVC）及外周血嗜酸性粒细胞（EOS）和白细胞介素-17（IL-17）等指标的变化。结果：2组治疗后喘息、咳嗽、咳痰、胸闷、呼吸困难及肺部哮鸣音等中医证候积分均得到明显改善，且治疗后观察组改善优于对照组，差异有统计学意义（P<0.05）；2组治疗后FEV1、PEF及FVC均明显提高，观察组改善优于对照组，差异有统计学意义（P<0.05）；2组治疗后EOS和IL-17水平均有下降，观察组改善优于对照组，差异有统计学意义（P<0.05）。结论：芥子防哮膏穴位贴敷联合平喘方治疗小儿哮喘临床疗效明显，可以显著改善患者中医证候积分、肺功能及免疫功能。
English Summary:
      To study the clinical effect of mustard antiasthmatic ointment acupoint application combined with Pingchuan Formula in the treatment of infantile asthma.Methods:From July 2017 to September 2018,a total of 40 child patients with asthma admitted to the First Affiliated Hospital of Heilongjiang University of Traditional Chinese medicine were selected as the study objects and were randomly divided into a control group and an observation group,with 20 cases in each group.The control group was given routine symptomatic treatment.The observation group was treated with acupoint application mustard antiasthmatic ointment combined with Pingchuan prescription on the basis of the control group.After 4 weeks of continuous treatment,the clinical efficacy was observed and the changes of TCM symptom score,first second forced expiratory volume(FEV1),maximum expiratory flow(PEF),vital capacity(FVC),peripheral blood eosinophils(EOS)and interleukin-17(IL-17)were compared between the 2 groups before and after treatment.Results:After treatment,the traditional Chinese medicine(TCM)scores such as asthma,cough,expectoration,chest tightness,dyspnea and wheezing sound of lungs in the 2 groups were significantly improved,and the improvement in the observation group was superior to that in the control group.The difference was statistically significant(P<0.05).FEV1,PEF and FVC in the 2 groups were significantly improved after treatment,and the improvement in the observation group was superior to that in the control group,the difference was statistically significant(P<0.05); after treatment,the levels of EOS and IL-17 decreased in both groups,and the improvement in the observation group was superior to that in the control group,with statistical significance(P<0.05).Conclusion:The clinical effects of acupoint application of mustard seed anti-asthma ointment combined with Pingchuan Formula in the treatment of infantile asthma is obvious,which can significantly improve the TCM symptoms score,pulmonary function and immune function of patients.
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