| 引用本文:秦万里1,2，曲剑华2，陈维文2，陈硕3.凉血除湿解毒法治疗寻常型银屑病有效性及安全性的系统评价及Meta分析[J].世界中医药,2020,(23):. |
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| 凉血除湿解毒法治疗寻常型银屑病有效性及安全性的系统评价及Meta分析 |
| Safety and Effectiveness of the Method of Cooling Blood Dehumidification and Detoxification on Psoriasis Vulgaris：a Systematic Review and Meta-analysis |
| 投稿时间：2019-06-26 |
| DOI：10.3969/j.issn.1673-7202.2020.23.019 |
| 中文关键词: 寻常型银屑病 凉血除湿解毒 随机对照 系统评价 Meta分析 |
| English Keywords:Psoriasis vulgaris Cool blood dehumidification and detoxification Randomized control System assesment Meta-analysis |
| 基金项目:基金项目：北京市属医院科研培育计划项目（PZ2017008） |
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| 中文摘要: |
| 目的：评价凉血除湿解毒法治疗寻常型银屑病的有效性与安全性。方法：计算机检索Cochrane图书馆、PubMed、Wiley、Ovid、Clinical Trials.gov、ChiCTR、中文期刊全文数据库（CNKI）、中文科技期刊数据库（VIP）、中国生物医学文献数据库（CBM）、万方数据库及SIGLE灰色文献数据库。检索建库至2019年3月关于凉血解毒法治疗寻常型银屑病的随机对照研究，依据Cochrane手册规定方法依次对文献进行筛选、数据提取和质量评价，采用RevMan5.3软件进行Meta分析。结果：最终共纳入10篇文献，789例寻常型银屑病患者，2篇为低偏倚文章，其余偏倚风险不确定。Meta分析结果显示凉血除湿解毒法可有效提高寻常型银屑病的临床有效率（OR=4.84，95%CI=3.09，7.56），降低PASI评分（MD=-2.81，95%CI=-3.98，-1.65）、DLQI评分（MD=-2.66，95%CI=-4.77，-0.55）,减少不良反应发生（OR=0.51，95%CI=0.09，2.84）。结论：目前证据支持凉血除湿解毒法可提高寻常型银屑病的临床疗效，改善患者的生命质量，且安全性较好。 |
| English Summary: |
| To evaluate of the effectiveness and safety of the method of cooling blood dehumidification and detoxification in the treatment of psoriasis.Methods:Computer search of Cochrane Library，PubMed，Wiley，Ovid，Clinical Trials.gov，ChiCTR，Chinese Journal Full-text Database(CNKI)，Chinese Science and Technology Journal Database(VIP)，Chinese Biomedical Literature Database(CBM)，Wanfang Database and SIGLE Gray Literature database were retrieved by computer.Randomized controlled studies on the treatment of psoriasis vulgaris with the method of cooling blood and detoxification were searched so far.According to the method specified in the Cochrane Handbook，the literature was screened，data extracted，and quality evaluated，and the RevMan5.3 software was used for meta-analysis.Results:In the end，a total of 10 literature were included，789 patients with psoriasis vulgaris，and 2 were with low-biased papers.The risk of other bias was uncertain.Meta-analysis showed that the method of cooling blood dehumidification and detoxification treatment of psoriasis vulgaris can effectively improve clinical effective rate［OR=4.91，95%CI(3.15，7.67)］，decrease PASI score［MD=-3.02，95%CI(-3.54，-2.50)］，DLQI［score MD=-2.79，95%CI(-3.86，-1.71)］and the incident of adverse reactions.Conclusion:The current evidence supports the method of cooling blood dehumidification and detoxification could improve the clinical efficacy of psoriasis vulgaris，improve the quality of life，with good safety. |
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