| 引用本文:张宗金，王悦芬，赵文景，崔方强，孟元，沈存，孙雪艳，王梦迪，刘梦超.基于轴探讨糖尿病肾病中医发病机制及治疗靶点[J].世界中医药,2020,(23):. |
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| 基于轴探讨糖尿病肾病中医发病机制及治疗靶点 |
| Discussion on the Pathogenesis and Treatment Target of Traditional Chinese Medicine of Diabetes Based on AGEs-RAGE Axis |
| 投稿时间：2019-08-30 |
| DOI：10.3969/j.issn.1673-7202.2020.23.029 |
| 中文关键词: 糖尿病肾病 非酶糖化 晚期糖基化终末产物-晚期糖基化终末产物受体轴 氧化应激 晚期糖基化终末产物抑制剂 晚期糖基化终末产物交联破坏剂 晚期糖基化终末产物-晚期糖基化终末产物受体通路阻断剂 抗氧化剂 中医治疗 邪伏膜原 |
| English Keywords:Diabetic nephropathy Non-enzymatic saccharification AGEs-RAGE axis Oxidative stress AGE inhibitors AGE cross-link breaker AGEs-RAGE pathway blocker Antioxidant Traditional Chinese medicine treatment Pathogen hidden in the pleurodiaphragmatic interspace |
| 基金项目:北京市自然科学基金项目(7172096) |
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| 中文摘要: |
| 糖尿病肾病（Diabetes Nephropathy，DN）是糖尿病（Diabetes Mellitus，DM）患者常见的微血管并发症，也是引起终末期肾脏病的主要原因之一。高糖环境下，非酶糖化反应生成的晚期糖基化终末产物（Advanced Glycationend Products，AGEs）和晚期糖基化终末产物受体（Receptors for Advanced Glycation End Products，RAGE）的相互结合和作用是DN发生和进展的重要原因之一。研究发现，作用于AGEs-RAGE轴的不同位点可以改善DN的症状，中医药通过抑制非酶糖化，减少AGEs形成和抑制RAGE方面改善DN，AGEs-RAGE轴在DN发病中具有伏邪特征。基于近几年实验研究热点，结合AGEs-RAGE轴进行总结论述，阐释“邪伏膜原”发病机制假说及中医治疗DN的作用机制。 |
| English Summary: |
| Diabetes nephropathy(DN)is a common microvascular complication in patients with diabetes mellitus(DM)，and it is also one of the main causes of end-stage renal disease.In high sugar environment，the interaction of advanced glycation end products(AGEs)and receptors(RAGE)produced by non-enzymatic glycation is one of the important reasons for the occurrence and progress of DN.It is found that different sites acting on AGEs-RAGE axis could improve DN symptoms.Traditional Chinese medicine(TCM)could improve DN by inhibiting non-enzymatic saccharification，reducing AGEs formation and inhibiting RAGE.AGEs-RAGE axis has the characteristics of incubating pathogens in DN.Based on the hotspot of experimental research in recent years，combined with AGEs-RAGE axis，we explain the pathogenesis hypothesis of “pathogen hidden in the pleurodiaphragmatic interspace” and the mechanism of TCM in the treatment of DN. |
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