To observe the effect of Shengjiang Powder and Xiaoxianxiong Decoction in the treatment patients with impaired glucose regulation of phlegm heat stasis syndrome and to preliminarily analyze the cause of its effect.Methods:A total of 84 elderly patients with impaired glucose regulation admitted to he Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine were divided into an observation group and a control group according to the random number table method,with 42 patients in each group.Patients in both groups were given routine measures such as lifestyle intervention.Patients in the control group were given metformin hydrochloride orally on the basis of this,and patients in the observation group were given Shengjiang Powder and Xiaoxianxiong Decoction on the basis of conventional measures.The changes of BMI,glucose and lipid metabolism index,TCM syndrome score and insulin resistance were compared before and after treatment.The serum levels of A-FABP,ADPN,IL-18 and TNF-αwere detected.Results:1) After treatment,the BMI,glucose and lipid metabolism indexes of the observation group improved significantly compared with the control group,and the levels of BMI,HbAlc,2 h PBG,FPBG,TC and TG were significantly lower than those of the control group (P<0.05).2) After treatment,the TCM syndrome score of the observation group was significantly lower than that of the control group (P<0.05).3) After treatment,2 hINS,FINS,HOMA-IR in the observation group were significantly lower than those in the control group,while HOMA-β were significantly higher than those in the control group (P<0.05).4) After treatment,the serum levels of A-FABP,IL-18 and TNF-α in the observation group were significantly lower than those in the control group,and the levels of ADPN were significantly higher than those in the control group (P<0.05).5) The effective rate of the observation group was 94.87% (37/39),which was significantly higher than that of the control group 80.00% (32/40),and the difference was statistically significant (χ2=3.950,P<0.05).Conclusion:Shengjiang Powder combined with Xiaoxianxiong Decoction beneficial to improve the clinical symptoms of patients with impaired glucose regulation,regulate glucose and lipid metabolism,reduce insulin resistance,and protect the function of pancreatic islet cells.The preliminary analysis may be related to down-regulating the expression of A-FAB,IL-18,TNF-αin serum,and increasing the level of ADPN,which is worthy of clinical promotion. |