| 引用本文:高娜1，姚涛1，赵赟1，李少康1，张平安2，车志英1.基于网络药理学探讨香砂六君子汤治疗慢性萎缩性胃炎的作用机制[J].世界中医药,2022,(04):. |
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| 基于网络药理学探讨香砂六君子汤治疗慢性萎缩性胃炎的作用机制 |
| Mechanism of Xiangsha Liujunzi Decoction in Treatment of Chronic Atrophic Gastritis Based on Network Pharmacology |
| 投稿时间：2021-01-20 |
| DOI：10.3969/j.issn.1673-7202.2022.04.004 |
| 中文关键词: 网络药理学 香砂六君子汤 慢性萎缩性胃炎 核心基因 基因本体功能注释 京都基因和基因组百科全书富集分析 “炎-癌”转化 |
| English Keywords:Network pharmacology Xiangsha Liujunzi Decoction Chronic atrophic gastritis Core gene GO gene function annotation KEGG enrichment analysis “Inflammation-cancer” transformation |
| 基金项目:2018年河南省科技攻关计划项目(182102310272);河南省中医药科学研究专项课题(20-21ZY2154);2020年河南中医药大学重点学科建设项目(15102044-2020-2) |
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| 中文摘要: |
| 目的:运用网络药理学的技术分析香砂六君子汤治疗慢性萎缩性胃炎的分子机制。方法:通过中药系统药理学数据库与分析平台（TCMSP）搜索香砂六君子汤的药物成分及靶点,绘制中药-化合物-靶点网络;通过GeneCards、OMIM数据库筛选疾病相关基因,绘制韦恩图,获取共同基因并绘制蛋白质-蛋白质相互作用(PPI)网络进行网络拓扑分析获取核心基因;对核心基因进行进一步的基因本体(GO)功能注释和京都基因和基因组百科全书(KEGG)通路富集分析。结果:经过筛选得到香砂六君子汤中药活性成分137个,潜在作用靶点162个,慢性萎缩性胃炎疾病702个相关靶点,药物-疾病共同靶点51个,经过网络拓扑分析得到PTGS2、TNF、VEGFA、IL1B、CAT等18个核心靶点,通过GO、KEGG主要富集于对活性氧的反应、细胞对氧化应激的反应等生物过程和肿瘤坏死因子、IL-17、Toll样受体、C型凝集素受体信号通路等通路上。结论:香砂六君子汤可以通过多成分-多靶点-多通路的机制,抑制“炎-癌”转化治疗慢性萎缩性胃炎。 |
| English Summary: |
| To explore the mechanism of Xiangsha Liujunzi Decoction in treating chronic atrophic gastritis by network pharmacology.Methods:The components and targets of Xiangsha Liujunzi Decoction were searched from TCMSP,and the drug-component-target network was plotted.Disease-related genes were screened out from GeneCards and OMIM for plotting the Venn diagram.The protein-protein interaction(PPI) network was delineated based on common genes for network topology analysis,and core genes were obtained.Gene Ontology(GO) functional enrichment and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment analyses were performed on the core genes.Results:After the screening,137 active components of Xiangsha Liujunzi Decoction,162 potential targets,702 related targets for chronic atrophic gastritis,and 51 common targets were obtained.Eighteen core targets,such as PTGS2,TNF,VEGFA,IL-1B,and CAT were obtained by network topology analysis,which were mainly enriched in biological processes,such as the response to reactive oxygen species and cell response to oxidative stress,and signaling pathways,such as TNF,IL-17,Toll-like receptor,and C-type lectin receptor,according to GO and KEGG analyses.Conclusion:Xiangsha Liujunzi Decoction can treat chronic atrophic gastritis through multi-component,multi-target,and multi-pathway,and inhibit the “inflammation-cancer” transformation of chronic atrophic gastritis. |
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