| 引用本文:罗晓欣1，周曼丽1，冯宇1，兰晓栋2，金梦雨2，徐思琦1，简维雄1.益气活血法治疗稳定型心绞痛临床疗效的Meta分析[J].世界中医药,2022,(04):. |
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| 益气活血法治疗稳定型心绞痛临床疗效的Meta分析 |
| Meta-analysis of Clinical Efficacy of Yiqi-Huoxue Therapy on Stable Angina |
| 投稿时间：2020-08-29 |
| DOI：10.3969/j.issn.1673-7202.2022.04.010 |
| 中文关键词: 稳定型心绞痛 益气活血 临床疗效 中西结合 中医 随机对照 循证医学 Meta分析 |
| English Keywords:Stable angina Yiqi-Huoxue Clinical efficacy Integrated traditional Chinese and western medicine Traditional Chinese medicine Randomized controlled trial Evidence-based medicine Meta-analysis |
| 基金项目:国家自然科学基金项目(81973753);湖南省自然科学基金项目(2018JJ2291) |
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| 中文摘要: |
| 目的:对运用中医益气活血为原则治疗稳定型心绞痛的临床疗效进行系统评价,为中医药治疗稳定型心绞痛提供循证医学依据。方法:检索国家知识基础设施数据库(CNKI);中国学术期刊数据库(CSPD);中文科技期刊数据库(CCD),中文生物医学文献数据库(CBM),纳入以益气活血为治疗原则,观察组采用中西结合、以中医为主的治疗,对照组以西药常规治疗的随机对照试验。严遵纳入排除标准筛选文献,对文献进行资料提取,应用RevMan 5.3软件对稳定型心绞痛的临床疗效进行Meta分析。疗效指标有:心绞痛治疗有效率、心电图改善及有效率、中医症状改善及有效率。结果:总纳入10篇文献,Meta分析心绞痛治疗有效率为RR=1.29,95%CI为1.08~1.55,Z=2.78,P=0.005,心电图改善有效率为RR=1.43,95%CI为1.29~1.59,Z=6.85,P<0.000 01,中医症状改善有效率为RR=1.29,95%CI为1.18~1.42,Z=5.41,P<0.000 01。结论:以益气活血原则为指导,在心绞痛发作频率及程度、心电图改善及中医症状改善方面,运用益气活血中药加常规西药治疗的临床效果均优于单纯西药治疗。 |
| English Summary: |
| To systematically evaluate the clinical efficacy on stable angina by Yiqi(qi benefiting)-Huoxue(blood activating) therapy in traditional Chinese medicine(TCM) to provide medical evidence for TCM treatment of stable angina.Methods:Randomized controlled trials(RCTs) on the treatment of stable angina by Yiqi-Huoxue therapy were searched from CNKI,CSPD,CCD,and CBM.In RCTs,the observation groups were treated by TCM assisted with western medicine,while the control groups were treated by western medicine only.Literature screening should strictly follow the inclusion and exclusion criteria.The data were extracted,and RevMan 5.3 was used for the Meta-analysis of the clinical efficacy on stable angina.The efficacy indicators included the response rate of angina treatment,the response rate of electrocardiogram(ECG) improvement,and the response rate of improvement of TCM symptoms.Results:Ten research articles were included.The Meta-analysis revealed the response rates of angina treatment(RR=1.29,95% CI [1.08,1.55],Z=2.78,P=0.005),ECG improvement(RR=1.43,95 % CI [1.29,1.59],Z=6.85,P<0.000 01),and improvement of TCM symptoms(RR=1.29,95% CI [1.18,1.42],Z=5.41,P<0.000 01).Conclusion:Based on Yiqi-Huoxue therapy,the clinical efficacy of Yiqi-Huoxue drugs combined with western medicine was superior to that of western medicine in terms of attack frequency and degree of angina,ECG improvement,and improvement of TCM symptoms. |
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