| To evaluate the application value of Xiaojin Capsules combined with traditional Chinese medicine(TCM) emotion therapy in the treatment of hyperplasia of mammary glands with qi stagnation and blood stasis syndrome and the influence on blood lipid and sex hormone levels.Methods:A total of 120 patients with breast gland hyperplasia with qi stagnation and blood stasis syndrome in the Surgery of Thyroid Gland and Breast,Hubei Provincial Hospital of Traditional Chinese Medicine were enrolled and randomly divided into an observation group(n=60) and a control group(n=60).The patients in the observation group received oral Xiaojin Capsules combined with TCM emotion therapy and those in the control group received oral tamoxifen.After 12 weeks of treatment,clinical efficacies,improvement in subjective symptoms(breast pain,breast mass size,and systemic concomitant symptoms),changes in blood lipid levels［including total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C)］,changes in sex hormone levels［prolactin(PRL),progesterone(P),and estradiol(E2)］ before and after treatment,mental status,improvement in quality of life,and adverse events of the two groups were compared.Results:The total effective rate in the observation group was 93.33%,higher than 80.22% in the control group(P<0.05).After treatment,the two groups showed relieved breast pain,reduced mass size,and improved systemic symptoms,and the observation group was superior with fewer adverse events(P<0.05).PRL and E2 in both groups decreased after treatment(P<0.05),and the decrease was more obvious in the observation group(P<0.05).There was no statistically significant difference in P before and after treatment(P>0.05).The levels of TG and LDL-C in the observation group decreased after treatment(P<0.05),and TC and HDL-C showed no significant changes(P>0.05).There was no significant difference in blood lipid indexes in the control group before and after treatment(P>0.05).The post-treatment levels of TG and LDL-C in the observation group were lower than those in the control group(P<0.05).The Symptom Checklist 90(SCL-90) scores of hostility,interpersonal sensitivity,depression,and anxiety in the observation group decreased after treatment,and were lower than those in the control group(P<0.05).Conclusion:Xiaojin Capsules combined with TCM emotion therapy can significantly relieve breast pain,reduce breast mass size,regulate the levels of sex hormones and blood lipids,and improve patients' adverse psychological state in the treatment of hyperplasia of mammary glands with few adverse events,which are worthy of clinical promotion. |
