| 引用本文:郭鹏翔1,2，杨扶德1，王志旺1，庞亚蓉1，丁茂鹏1，韦凌霞1.党参对慢性阻塞性肺疾病模型小鼠炎症介质的影响[J].世界中医药,2022,(20):. |
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| 党参对慢性阻塞性肺疾病模型小鼠炎症介质的影响 |
| Therapeutic Effects of Codonopsis Radix on the Mouse Model of Chronic Obstructive Pulmonary Disease |
| 投稿时间：2021-01-11 |
| DOI：10.3969/j.issn.1673-7202.2022.20.004 |
| 中文关键词: 党参 慢性阻塞性肺疾病 小鼠 炎症介质 核因子κB 细胞因子 治疗作用 肺组织 |
| English Keywords:Codonopsis Radix Chronic obstructive pulmonary disease(COPD) Mice Inflammatory factors Nuclear factor kappa B Cytokines Therapeutic effects Lung tissue |
| 基金项目:科技部国家重点研发计划“中医药现代化研究”重点专项（2018YFC1706305） |
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| 中文摘要: |
| 目的：研究党参对慢性阻塞性肺疾病（COPD）模型小鼠的治疗作用及对炎症介质的影响。方法：采用经鼻滴注COPD造模液的方法复制COPD小鼠模型，经受试药干预，观测COPD小鼠行为学、肺组织湿干重比值、肺组织中炎症介质白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）及核因子κB的变化，研究党参对COPD的治疗作用及其机制。结果：10.4 g/kg、5.2 g/kg、2.6 g/kg党参可明显改善小鼠抓鼻、挠痒及呼吸异常等COPD行为学，降低肺组织湿干重比值及IL-1β、IL-6、IL-8含量，下调肺组织核因子κB的表达水平（P<0.05，P<0.01）。结论：党参具有治疗COPD的作用，下调炎症介质表达而缓解气道炎症是其作用机制之一。 |
| English Summary: |
| To study the therapeutic effects of Codonopsis Radix on chronic obstructive pulmonary disease(COPD) and its effect on inflammatory factors in the mouse model of COPD.Methods:The mouse model of COPD was replicated by the nasal drip of COPD-establishing liquid,and the changes in behavior,lung wet/dry weight ratio,and inflammatory factors ［interleukin-1β(IL-1β),interleukin-6(IL-6),interleukin-8(IL-8),and nuclear factor kappa B(NF-κB)］ in the mouse model of COPD were observed after trial drug intervention.The therapeutic effects of Codonopsis Radix on mice with COPD and its mechanism were studied.Results:The 10.4 g/kg,5.2 g/kg,and 2.6 g/kg Codonopsis Radix significantly improved the COPD behaviors of mice such as scratching nose,scratching,and abnormal respiration,reduced lung wet/dry weight ratio and the content of IL-1β,IL-6,and IL-8,and down-regulated the expression levels of NF-κB in the lung tissue(P<0.05,P<0.01).Conclusion:Codonopsis Radix has therapeutic effects on COPD,and one of its mechanisms is to down-regulate the expression of inflammatory factors and alleviate airway inflammation. |
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