世界中医药

目的：探究百乐眠胶囊联合阿戈美拉汀对轻中度抑郁症患者的治疗效果。方法：选取2020年1月至2021年12月青海省第三人民医院收治的轻中度抑郁症患者140例作为研究对象，按照随机数字表法分为对照组和观察组，每组70例。对照组采用阿戈美拉汀治疗,观察组在对照组的基础上采用百乐眠胶囊治疗,疗程均为1个月。比较2组疗效、血清血清神经肽Y(NPY)、5-羟色胺（5-HT）、3,4-二羟苯乙酸(DOPAC)、去甲肾上腺素(NE)、脑源性神经营养因子(BDNF)、S100钙结合蛋白B（S100B）、髓鞘碱性蛋白(MBP)水平、匹兹堡睡眠质量指数量表(PSQI)、汉密顿抑郁量表(HAMD)、生命质量问卷(QLQL-74)、巴塞尔指数（BI）评分及不良反应。结果：治疗后,观察组总有效率为91.43%,高于对照组的78.57%，差异有统计学意义(P<0.05)。与治疗前比较,治疗后2组血清NPY、5-HT、DOPAC、NE、BDNF水平及QLQL-74、BI评分升高,上述指标观察组高于对照组，差异均有统计学意义(均P<0.05);2组血清S100B、MBP水平、PSQI评分及HAMD评分降低,上述指标观察组低于对照组，差异均有统计学意义(均P<0.05)。治疗期间,对照组总不良反应发生率为14.29%,总不良反应发生率为18.57%,差异无统计学意义(P>0.05)。结论：百乐眠胶囊联合阿戈美拉汀治疗轻中度抑郁症患者,可有效改善血清NPY、5-HT、DOPAC、NE水平和神经营养状态,提高其睡眠质量,改善其心理状态、生命质量及生活能力,具有较好的治疗效果和安全性。

English Summary:

To explore the therapeutic effect of Bailemian Capsules combined with agomelatine on patients with mild-to-moderate depression.Methods:A total of 140 patients with mild-to-moderate depression admitted to the Third People's Hospital of Qinghai Province from January 2020 to December 2021 were selected and randomly divided into a control group(n=70) and an observation group(n=70) by random number table method.The patients in the control group were treated with agomelatine，and those in the observation group were treated with Bailemian Capsules combined with agomelatine.After treatment for one month，the clinical efficacy，serum neuropeptide Y(NPY)，5-hydroxytryptamine(5-HT)，3,4-dihydroxyphenylacetic acid(DOPAC)，norepinephrine(NE)，brain-derived neurotrophic factor(BDNF)，S100 calcium-binding protein B(S100B)，myelin basic protein(MBP)，scores of Pittsburgh Sleep Quality Index(PSQI)，Hamilton Depression Scale(HAMD)，quality of life questionnaire(QLQ-74)，and Barthel Index(BI)，and adverse reactions were compared between the two groups.Results:After treatment，the total effective rate of the observation group was 91.43%，which was higher than 78.57% of the control group(P<0.05).The levels of serum NPY，5-HT，DOPAC，NE，BDNF，and scores of QLQ-74 and BI in the two groups increased after treatment as compared with those before treatment，and the observation group was higher than the control group(P<0.05).The levels of serum S100B，MBP，PSQI score，and HAMD score of the two groups decreased after treatment，and the observation group was lower than the control group(P<0.05).During the treatment，the total incidence of adverse reactions was 14.29% in the control group and 18.57% in the observation group(P>0.05).Conclusion:Bailemian Capsules combined with agomelatine can effectively improve the levels of serum NPY，5-HT，DOPAC，NE，and neurotrophic status of patients with mild-to-moderate depression and improve their sleep quality，psychological state，quality of life，and life ability，with a good therapeutic effect and safety.

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