| 引用本文:黄远程1，邹雨杉1，黄超原1，沈丹婷1，田燕华1，文艺2，李培武2，刘凤斌2，3.胃息肉证候与用药规律的文献研究[J].世界中医药,2023,(04):. |
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| 胃息肉证候与用药规律的文献研究 |
| Literature Review of TCM Syndromes of Gastric Polyp and Medication Rules |
| 投稿时间：2021-12-16 |
| DOI：10.3969/j.issn.1673-7202.2023.04.017 |
| 中文关键词: 胃息肉 数据挖掘 文献研究 中医传承辅助平台 证候 证素 关联规则 用药规律 |
| English Keywords:Gastric polyps Data mining Literature review Traditional Chinese Medicine Inheritance Support System Syndrome Syndrome elements Association rules Medication rules |
| 基金项目:国家自然科学基金项目（81904139）；国家中医药管理局区域中医（专科）诊疗中心建设与培育项目(国中医药医政函〔2018〕205号)；刘凤斌广东省名中医传承工作室（粤中医办函〔2020〕1号）；广州中医药大学“双一流”与高水平大学学科协同创新团队项目［2021xk47］-中医药防治胃“炎-癌”转化的协同创新团队 |
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| 中文摘要: |
| 目的：探讨胃息肉（GP）的证候与用药规律，为该病临床辨证论治提供依据与方向。方法：检索国家知识基础设施数据库（CNKI）、中国学术期刊数据库（CSPD）、中文科技期刊数据库（CCD）、中国生物医学文献数据库（CBM）、Embase数据库和PubMed数据库，依据纳入和排除标准，纳入GP的中医临床研究。收集文献的辨证分型与处方用药，应用SPSS 22.0统计软件分析证候规律，应用中医传承辅助平台（V2.5）进行描述性统计、关联规则运算，分析用药规律。结果：共纳入文献53篇。脾胃阳虚证、肝胃不和证、脾胃湿热证、气滞痰阻证、脾胃气虚证为GP主要证候类型。GP病位在胃、脾、肝。GP常见病性类证素依次为气滞、湿、热、痰、气虚。GP中药处方包含中药共127味。在支持数为3、5、7和置信度为60%的筛选标准下进行关联规则分析，分别得到药物间关联规则365、69、28条，主要用药组合分别为30、17、14个。结论：GP为本虚标实、虚实夹杂之证，本虚主要是脾气（阳）虚，标实主要是气滞、湿热、痰阻，病位在脾胃，与肝密切相关，气滞、湿、热、痰、气虚是关键病理因素。GP以益气健脾为基本治法，辅以理气、除湿化痰、活血、清热等法，以六君子汤合丹参饮加减为基础方。 |
| English Summary: |
| To investigate the traditional Chinese medicine(TCM) syndromes of gastric polyps(GP) and medication rules to provide references for the clinical treatment of GP based on syndrome differentiation.Methods:CNKI，CSPD，CCD，CBM，Embase，and PubMed were searched for clinical studies of GP according to inclusion and exclusion criteria.The syndrome types and TCM prescriptions were collected and analyzed for syndrome rules by SPSS 22.0，followed by descriptive statistics and association rules algorithm through Traditional Chinese Medicine Inheritance Support System(TCMISS，V2.5).Finally，the medication rules were analyzed.Results:Fifty-three research articles were finally included.The main syndromes of GP were yang deficiency of the spleen and the stomach，disharmony of the liver and the stomach，heat and dampness of the spleen and the stomach，qi stagnation and phlegm obstruction，and qi deficiency of the spleen and the stomach.The disease was located in the stomach，the spleen，and the liver.The common syndrome elements of GP were qi stagnation，dampness，heat，phlegm，and qi deficiency.The prescriptions against GP involved 127 drugs.Association rules were analyzed under the screening criteria of support of 3，5，7，and 60% confidence，and 365，69，and 28 association rules were obtained，with 30，17，and 14 drug combinations，respectively.Conclusion:The TCM syndromes of GP are characterized by asthenia in origin and sthenia in superficiality and deficiency-excess in complexity.Specifically，the asthenia in origin is reflected in(yang) deficiency of spleen qi，and the sthenia in superficiality is in qi stagnation，dampness and heat，and phlegm obstruction.The disease is located in the spleen and the stomach，closely related to the liver.The main pathogenic elements are qi stagnation，dampness，heat，phlegm，and qi deficiency.The treatment principles of GP should be based on replenishing qi to invigorate the spleen，combined with regulating qi，removing dampness，resolving phlegm，activating blood，and clearing heat.The basic prescription is Liujunzi Decoction combined with Danshen Decoction with modifications. |
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