| 引用本文:曾胜澜1，王娜2，张荣臻2，毛德文2.肠道菌群在肝细胞癌中的作用机制及治疗进展[J].世界中医药,2023,(06):. |
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| 肠道菌群在肝细胞癌中的作用机制及治疗进展 |
| Progress in Role and Application of Intestinal Microbiota in Hepatocellular Carcinoma |
| 投稿时间：2021-07-19 |
| DOI：10.3969/j.issn.1673-7202.2023.06.026 |
| 中文关键词: 肝细胞癌 肠道菌群 慢性肝病 肠渗漏 代谢产物 治疗 中医药 |
| English Keywords:Hepatocellular carcinoma Intestinal microbiota Chronic liver disease Intestinal leakage Metabolites Treatment Traditional Chinese medicine |
| 基金项目:国家自然科学基金项目（81774236，81960841）——解毒化瘀颗粒通过miRNAs/NF-κB/ROS调控NLRP3炎症体活化拮抗肝衰竭的机制研究；基于胆汁酸-FXR-肠道微生态探索解毒化瘀颗粒促进肝干细胞转化拮抗肝衰竭的分子机制 |
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| 中文摘要: |
| 肝癌发病率和死亡率较高，是全世界癌症死亡的主要病因之一，肝癌的发病原因与各种慢性肝病相关，如肝硬化、病毒性肝炎等，其治疗较为困难，目前尚无较好的早期诊断方法和治疗方案。肠道中有大量的微生物，其附着在肠道的表面，肠道屏障可避免肠道内的细菌与人体直接接触，另外，肠道细菌也是人体内代谢的重要参与者，肠道菌群在人体中的作用已逐步受到重视，已有研究证明其在人体疾病进展中发挥作用，对肠道菌群的研究有助于了解相关疾病的发生机制。综述肠道菌群在肝细胞癌中的作用机制，包括二者联系的纽带肠-肝轴，及其与慢性肝病之间的联系和代谢产物相关通路在肝细胞癌发生发展中的作用，总结目前一些与肠道菌群相关的治疗肝细胞癌的中西医方案，发现中医药在缓解肝癌患者临床症状方面也有一定的作用。可为肝细胞癌的基础理论研究和治疗提供参考。 |
| English Summary: |
| Liver cancer with a high incidence and mortality is the main cause of cancer death all over the world.The occurrence of liver cancer is associated with chronic liver diseases，such as cirrhosis and viral hepatitis.This disease can hardly be cured，and the early diagnosis method and treatment regimen remain to be developed.Intestinal microbiota refers to a large number of microorganisms on the intestinal surface.The intestinal barrier can avoid the direct contact between the bacteria in the intestinal tract and the human body.Since intestinal microbiota is an important participant in the metabolism，its roles in the human body have been extensively studied.Studies have proved that intestinal microbiota plays a role in the progression of human diseases.The research on intestinal microbiota is conducive to deciphering the mechanism of related diseases.This article reviews the role of intestinal microbiota in hepatocellular carcinoma(including the gut-liver axis)，the relationship between intestinal microbiota and chronic liver diseases，and the role of metabolite-related pathways in the occurrence and development of hepatocellular carcinoma.Furthermore，this article summarizes the current Chinese and western medicine protocols involving intestinal microbiota in the treatment of hepatocellular carcinoma，and finds that traditional Chinese medicine can relieve the clinical symptoms of the patients.This article can provide reference for the theoretical research and treatment of hepatocellular carcinoma. |
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