| 引用本文:汪阳1，杨硕2，高毛毛1，孙立亚1.平肝潜阳中药治疗肝阳上亢型高血压的分子机制研究[J].世界中医药,2023,(19):. |
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| 平肝潜阳中药治疗肝阳上亢型高血压的分子机制研究 |
| Molecular Mechanism of Pacifying Liver and Subduing Yang in the Treatment of Hypertension with Ascendant Hyperactivity of Liver Yang |
| 投稿时间：2022-08-31 |
| DOI：10.3969/j.issn.1673-7202.2023.19.025 |
| 中文关键词: 平肝潜阳 平抑肝阳 中药 肝阳上亢 高血压 分子机制 研究 |
| English Keywords:Pacifying liver and subduing yang Calming and inhibiting liver yang Chinese medicinal material Ascendant hyperactivity of liver yang Hypertension Molecular mechanism Research |
| 基金项目:国家重点研发计划战略性国际科技创新合作重点专项（2016YFE0205400）——H型高血压管理与脑卒中预防战略性国际科技创新合作 |
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| 中文摘要: |
| 肝阳上亢型高血压的核心病机是肝肾阴虚、水不涵木、阴不制阳、肝阳上亢，临床一般采用平肝潜阳法治疗。常用方剂有天麻钩藤饮、镇肝熄风汤、建瓴汤等，常用中药包括：石决明、珍珠母、牡蛎、紫贝齿、代赭石、刺蒺藜、罗布麻、生铁落等，这些中药均具有平抑肝阳的作用，并且能够通过多角度、多层面、多靶点的作用发挥疗效。通过对国内外近年相关文献进行梳理，发现其分子机制主要涉及调节修复血管、调节微循环障碍、调节炎症反应、防治靶器官损害、调节免疫功能障碍、调节代谢过程等。本研究旨在为中药治疗肝阳上亢型高血压提供理论支持，促进平肝潜阳中药的基础研究进一步发展，为肝阳上亢型高血压的遣方用药提供新思路，从而更好的研发新药用于临床治疗。 |
| English Summary: |
| The core pathogenesis of hypertension with ascendant hyperactivity of liver yang is liver-kidney yin deficiency，water failing to nourish wood，yin failing to control yang，and ascendant hyperactivity of liver yang，which is usually treated by pacifying liver and subduing yang in clinical practice.Commonly used prescriptions include Tianma Gouteng Decoction，Zhengan Xifeng Decoction，and Jianling Decoction，and commonly involved medicinal materials include Concha Hailotidis，Concha Margaritifera，Concha Ostreae，Concha Mauritiae Arabicae，Haematitum，Fructus Tribuli，Apocyni Veneti，and Ferrum Squamae.These medicinal materials，with the effect of calming and inhibiting liver yang，exert their curative effects through multi-angle，multi-level and multi-target ways.This paper analyzed the relevant literature in China and abroad in recent years，and found that the molecular mechanism mainly involved regulating and repairing blood vessels，regulating microcirculation disorders and inflammatory response，preventing target organ damage，modulating immune dysfunction，modulating metabolic processes，etc.This paper aimed to provide theoretical support for the treatment of hypertension with ascendant hyperactivity of liver yang with traditional Chinese medicine，promote the further development of basic research on pacifying liver and subduing yang，and provide new ideas for the prescription and medication of hypertension with ascendant hyperactivity of liver yang，thereby facilitating the research and development of new drugs for clinical treatment. |
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