| 引用本文:游雪娟1，李丽青2，冯珂1，纪立金1.方剂有毒药物配伍“增效减毒”的现代研究进展[J].世界中医药,2024,(01):. |
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| 方剂有毒药物配伍“增效减毒”的现代研究进展 |
| Modern Research Progress on “Enhancing Efficacy while Reducing Toxicity” of Toxic Drugs in Traditional Chinese Medicine Formulas |
| 投稿时间：2022-05-19 |
| DOI：10.3969/j.issn.1673-7202.2024.01.001 |
| 中文关键词: 方剂 有毒中药 配伍 增效 减毒 增效减毒 现代研究 研究进展 |
| English Keywords:Prescription Toxic Chinese medicine Compatibility Of medicines Enhancing efficacy Reducing toxicity Enhancing efficacy while reducing toxicity Modern research Research progress |
| 基金项目:国家自然科学基金面上项目（81373528）；福建省自然基金面上项目（2020J01739） |
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| 中文摘要: |
| 方剂配伍包含了君臣佐使配伍、七情配伍、药性配伍（四气五味、升降浮沉、性味归经）。古代将一切治疗疾病的药物统称为毒药，按不良反应大小来分；现代则是以对人体不良影响为不良反应。增效即是相须相使，减毒即是相畏相杀。现回顾近年来相关文献，从方剂有毒药物配伍增效减毒内涵、规律和现代科技增效减毒新工艺为3个方面，重点从方剂有毒药物配伍增效减毒规律所包括的君臣佐使法，拆方法，药味、药量变化法，合方法，补脾护胃、顾护中气法、性效相制相成法等探讨方剂有毒药物配伍“增效减毒”的现代研究进展。 |
| English Summary: |
| The compatibility of traditional Chinese medicine formulas involves the combination of king，minister，assistant，and envoy herbs，as well as considerations for seven emotions，drug properties(four qi，five flavors，ascending，descending，floating，sinking，and the nature and taste returning to specific meridians).In ancient times，all medicinal substances used for treating diseases were collectively referred to as toxic drugs，categorized based on the severity of adverse reactions.In modern times，toxicity is assessed based on adverse effects on the human body.Enhancing efficacy refers to the synergy between herbs，while reducing toxicity involves counteracting or neutralizing toxic effects.The authors reviewed related literature in recent years.The modern research progress on the compatibility of toxic drugs in traditional Chinese medicine formulas，focusing on “enhancing efficacy while reducing toxicity,” can be categorized into three aspects：the connotation，principles，and modern technological advancements.This includes exploring the rules of enhancing efficacy and reducing toxicity in the compatibility of toxic drugs in traditional Chinese medicine formulas，such as the use of king，minister，assistant，and envoy herbs，herb separation methods，variations in taste and dosage，combination methods，tonifying the spleen and protecting the stomach，safeguarding the middle qi，and the mutual restriction and enhancement of herb properties and effects. |
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