引用本文:张淼1,马帅2,张思琪2,杨添淞3.阿尔茨海默病中小胶质细胞的作用及针刺干预研究概况[J].世界中医药,2024,(01):. |
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阿尔茨海默病中小胶质细胞的作用及针刺干预研究概况 |
The Role of Microglia in Alzheimer's Disease and Acupuncture Regulation of Microglia in the Treatment |
投稿时间:2022-05-30 |
DOI:10.3969/j.issn.1673-7202.2024.01.001 |
中文关键词: 阿尔茨海默病 针刺 小胶质细胞 神经炎症 自噬 突触可塑性 退行性疾病 综述 |
English Keywords:Alzheimer's disease Acupuncture Microglia Neuroinflammation Autophagy Synaptic plasticity Degenerative disease Review |
基金项目:国家自然科学基金项目(8217152653);黑龙江省博士后科研启动资金项目(LBH-Q18123);黑龙江省自然科学基金联合引导项目(LH2019H047) |
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中文摘要: |
阿尔茨海默病是最常见的神经退行性疾病,该病病因病机尚不明确,目前仍缺乏有效的治疗药物和治疗方法。小胶质细胞作为中枢神经系统固有的先天免疫细胞,其介导的神经炎症在阿尔茨海默病发病机制中起着核心作用,而自噬的激活可以减少神经细胞凋亡,抑制神经炎症。针刺对于治疗阿尔茨海默病疗效显著,且对小胶质细胞具有调控作用,能抑制中枢性炎症、激活自噬功能、调节突触可塑性。 |
English Summary: |
Alzheimer's disease is the most common neurodegenerative disease,and its etiology and pathogenesis are still unclear.Currently,effective treatment drugs and methods are lacking.Microglia,as the innate immune cells of the central nervous system,play a central role in mediating neuroinflammation in the pathogenesis of Alzheimer's disease.Activation of autophagy can reduce neuronal apoptosis and inhibit neuroinflammation.Acupuncture has a significant therapeutic effect on Alzheimer's disease and has a regulatory effect on microglia,which can inhibit central inflammation,activate autophagy,and regulate synaptic plasticity. |
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