| 引用本文:张燕1，杨建英1，王钦1，廖佳禾1，黄子玮1，罗静2，3，陶庆文2，3.原发性干燥综合征合并血细胞减少中医诊治研究进展[J].世界中医药,2024,(02):. |
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| 原发性干燥综合征合并血细胞减少中医诊治研究进展 |
| Research Progress in TCM Diagnosis and Treatment of Primary Sjgren's Syndrome Complicated with Hemocytopenia |
| 投稿时间：2023-03-03 |
| DOI：10.3969/j.issn.1673-7202.2024.02.019 |
| 中文关键词: 干燥综合征 血细胞减少 贫血 白细胞减少 血小板减少 中医 诊治经验 研究进展 |
| English Keywords:Sjgren's syndrome Hemocytopenia Anemia Leukopenia Thrombocytopenia Traditional Chinese medicine Experience in diagnosis and treatment Research progress |
| 基金项目:国家自然科学基金青年科学基金项目（81804042）;中央高水平医院临床科研业务费资助项目（2022-NHLHCRF-LX-02-0103）；首都卫生发展科研专项青年优才项目（2020-4-40610）；中日友好医院“菁英计划”人才培育工程项目（ZRJY2021-QM14） |
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| 中文摘要: |
| 原发性干燥综合征（pSS）是一种慢性炎症性自身免疫病，除累及外分泌腺之外，还可累及多器官、系统，其中以血液系统受累最为常见，多表现为一系或多系血细胞减少。目前对于pSS合并血细胞减少缺乏统一公认的治疗方案，西医治疗多以糖皮质激素、免疫抑制剂为主，而中医药治疗本病具有较好疗效。通过总结pSS合并血细胞减少的中医诊治经验，并对相关研究进行综述后发现，现代医家认为pSS核心病机为气阴亏虚，久之则产生热、毒、瘀等多种病理产物，相互影响，导致全身气血津液失常，引起血细胞减少。本病病位多责之于肝、脾、肾，治以滋阴、益气、养血之法，辅以清热解毒、化瘀通络之法，并根据其合并血细胞减少类型的不同以及是否使用糖皮质激素用药各有侧重。中医药治疗本病较西药治疗能够更好地改善血细胞水平且不良事件发生率更低，具有一定优势。 |
| English Summary: |
| Primary Sjgren's syndrome(pSS) is a chronic inflammatory autoimmune disease that involves not only exocrine glands，but also multiple organs and systems.Among them，the blood system is the most commonly involved，usually manifested as hemocytopenia in one or multiple lineages.There is a lack of universally recognized therapy for pSS with hemocytopenia.Western medicine mainly focuses on glucocorticoids and immunosuppressants，while traditional Chinese medicine(TCM) has a good effect on the treatment of this disease.This article summarized the experience of TCM diagnosis and treatment and related studies of pSS with hemocytopenia，in order to provide reference for TCM clinical treatment of this disease.Modern TCM experts believe that the core pathogenesis of pSS is dual deficiency of qi and yin.After a long-term disease duration，a variety of pathological products such as heat，toxin，and blood stasis were produced，which interact with each other，leading to disorders of qi，blood，and body fluid，and eventually causing hemocytopenia.This disease occurred in the liver，spleen and kidney，and the treatment methods are mainly nourishing Yin，tonifying qi and blood，supplemented by the method of clearing heat and removing toxins，resolving stasis and dredging collaterals.Furthermore，the emphasis of medication was adjusted according to the different types of hemocytopenia and whether glucocorticoids are used.Compared with western medicine，TCM has certain advantages which can better improve blood cell count and lower the incidence of adverse events. |
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