| 引用本文:马重阳1，徐甜2，蒋欣妤1，陈佳慧2，殷秀敏3，程发峰2，王雪茜2，王庆国2，张秋云1.基于方元的《伤寒论》用药规律研究[J].世界中医药,2024,(05):. |
|
| 基于方元的《伤寒论》用药规律研究 |
| Research on Medication Rules of Treatise on Febrile Diseases Based on Fang Yuan |
| 投稿时间：2022-07-18 |
| DOI：10.3969/j.issn.1673-7202.2024.05.019 |
| 中文关键词: 经方 方元 方剂结构 方剂相似性 关联规则 社团结构 伤寒论 数据挖掘 |
| English Keywords:Classic prescription Fang Yuan Prescription structure Prescription similarity Association rules Community structure Treatise on Febrile Diseases Data mining |
| 基金项目:国家自然科学基金项目（82004327）；第六批北京市级中医药专家学术经验继承项目 |
|
| 摘要点击次数: 388 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的：方元被定义为组成《伤寒论》中方剂有规律可循的最小方剂单元，既体现了方剂的组方特色，又便于临床灵活化裁。本研究拟通过数据挖掘方法，从方元的角度分析《伤寒论》的用药规律。方法：本研究运用R语言计算不同方剂之间Jaccard相似系数及不同中药之间的关联规则，并使用网络社团结构分析，进行《伤寒论》中方元的识别。结果：《伤寒论》中所有方剂的相似性明显高于《方剂学》教材中方剂的相似性，表明方剂中存在更小的方剂单元。关联规则及社团分析能够识别方元，如2味药方元石膏-甘草、桂枝-当归、栀子-香豉等，以及3味药方元干姜-黄连-人参、当归-细辛-通草、麻黄-桂枝-杏仁等。结论：《伤寒论》中存在2味或3味药构成的方元，未来需要对这些方元进行临床或实验上的验证，以明确方元的功效，指导临床应用。 |
| English Summary: |
| Fang Yuan is defined as the smallest unit of prescription composition in Treatise on Febrile Diseases，which not only reflects the characteristics of prescription formulation but also facilitates flexible application in clinical practice.This study aims to analyze the medication rules in Treatise on Febrile Diseases from the perspective of Fang Yuan using data mining methods.Methods:In this study，R language was employed to calculate the Jaccard similarity coefficient between different prescriptions and the association rules among various Chinese medicinal herbs.Network community structure analysis was utilized to identify Fang Yuan in Treatise on Febrile Diseases.Results:The similarity among all prescriptions in Treatise on Febrile Diseases was significantly higher than that of prescriptions in the textbook of Fang Ji Xue，indicating the existence of smaller prescription units.Association rules and community analysis were able to identify Fang Yuan，such as Fang Yuan composed of two medicinal herbs including gypsum-licorice，cassia twig-angelica sinensis，gardenia-fermented soybeans，as well as Fang Yuan composed of three medicinal herbs such as dried ginger-coptis-ginseng，angelica sinensis-asarum-woody nightshade，and ephedra-cassia twig-apricot seed.Conclusion:Treatise on Febrile Diseases contains Fang Yuan composed of two or three medicinal herbs.Future research should validate these Fang Yuan clinically or experimentally to clarify their therapeutic effects and guide their application in clinical practice. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
