| 引用本文:陈雪妍1,2，黄梦妮1,2，秦秀德1,2，江丰3，莫嘉欣4.脑小血管病认知功能障碍的中医药防治研究进展[J].世界中医药,2024,(05):. |
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| 脑小血管病认知功能障碍的中医药防治研究进展 |
| Research Progress in TCM Prevention and Treatment of Vascular Cognitive Impairment Caused by Cerebral Small Vessel Disease |
| 投稿时间：2022-10-24 |
| DOI：10.3969/j.issn.1673-7202.2024.05.025 |
| 中文关键词: 脑小血管病 认知功能障碍 病因 病机 证型 治疗 研究进展 |
| English Keywords:Cerebral small vessel disease Cognitive impairment Etiology Pathogenesis Syndrome Treatment Research progress |
| 基金项目:国家自然科学基金项目(81804004)——脑髓康通过调控CypA/NF-κB/MMP9通路保护血脑屏障及Aβ转运机制改善痴呆动物模型认知功能的机制研究；国家自然科学基金项目(81904103)——从NS1拮抗IFN-β作用途径探讨基于“风热毒”邪论治的热毒宁注射液抗甲型H1N1流感病毒机制；深圳市“医疗卫生三名工程”项目(SZZYSM 202111011)——天津中医药大学张伯礼院士中医临床团队 |
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| 中文摘要: |
| 脑小血管病认知功能障碍（CSVD-VCI）是在脑小血管病基础上，引起认知功能受损的一类临床综合征。近年来，随着人口老龄化的加速，CSVD-VCI的发病率逐年上升，早诊断早治疗对该病的防治具有重要意义。CSVD-VCI属于中医学健忘、痴呆的范畴，中医学认为其病机涉及虚、痰、瘀、毒等多种因素，可分为脏腑亏虚型、痰瘀阻络型、毒损脑络型等主要证候类型。中医通过辨证论治在该病的治疗中发挥着重要作用，并取得显著进展，本文就CSVD-VCI的病因病机、辨证分型以及近年来中药单药、复方治疗该病的动物实验和临床研究展开综述，为中医药治疗CSVD-VCI提供参考依据。 |
| English Summary: |
| Vascular cognitive impairment caused by cerebral small vessel disease(CSVD-VCI) is a clinical syndrome of cognitive impairment on the basis of cerebral small vessel disease.As population aging is accelerating in recent years，the incidence of CSVD-VCI is increasing year by year.Early diagnosis and treatment are of great significance to the prevention and treatment of CSVD-VCI.According to the TCM theory，CSVD-VCI is a disease of amnesia and dementia caused by multiple factors including deficiency，phlegm，stasis，and toxin.The patients mainly present the syndromes of deficiency in zang-fu organs，phlegm-stasis obstructing collaterals，or toxin damaging brain collateral.TCM plays an important role in the diagnosis and treatment of CSVD-VCI based on syndrome differentiation.Therefore，this paper reviews the research progress in the etiology，pathogenesis，syndrome differentiation of CSVD-VCI as well as the animal experiments and clinical trials about the treatment of this disease with single Chinese medicines and TCM compound prescriptions，aiming to provide a reference for the TCM treatment of CSVD-VCI. |
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