| 引用本文:宋慧平1，2，岳傲春3，李泽坤3，韩伟2，李琴2，4.大鼠急性血瘀证模型造模方法的网状Meta分析[J].世界中医药,2024,(08):. |
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| 大鼠急性血瘀证模型造模方法的网状Meta分析 |
| Network Meta-Analysis of Modeling Methods for Rats with Acute Blood Stasis Syndrome |
| 投稿时间：2022-07-19 |
| DOI：10.3969/j.issn.1673-7202.2024.08.007 |
| 中文关键词: 急性血瘀证 动物模型 造模方法 大鼠 模型评价 实验方法 网状Meta分析 系统评价 |
| English Keywords:Acute blood stasis syndrome Animal model Modeling methods Rats Assessment of model Experimental methods Network meta-analysis Systematic review |
| 基金项目:国家自然科学基金项目（82071465，81571283）；山东省自然科学基金项目（ZR2020MH154，ZR2016HL21）；山东省重点研发项目（2018GSF118215）；深圳市医疗卫生三名工程项目（SZSM201911007） |
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| 中文摘要: |
| 目的：采用网状Meta分析评价不同急性血瘀证模型造模方法的效果，为中医实验研究急性血瘀证动物模型的制备提供循证依据。方法：检索中国期刊全文数据库（CNKI）、中国学术期刊数据库（CSPD）、中文科技期刊数据库（CCD）中有关急性血瘀证模型的建模方法，应用Stata软件进行网状Meta分析。结果：最终纳入32项研究，共纳入9种造模方案。各项指标最优前3位概率排序分别为：1）全血黏度：1 S-1切变率右旋糖酐＞高脂＞氢化可的松+肾上腺素，10 S-1切变率冰水浴＞肾上腺素＞高脂+力竭游泳，30 S-1切变率多因素刺激＞右旋糖酐＞肾上腺素，60 S-1切变率多因素刺激＞右旋糖酐＞肾上腺素，150 S-1切变率肾上腺素＞冰水浴＞高脂+力竭游泳，200 S-1切变率右旋糖酐＞氢化可的松+肾上腺素＞角叉莱胶+内毒素；2）血浆黏度：右旋糖酐＞多因素刺激＞肾上腺素；3）红细胞聚集指数：冰水浴＞多因素刺激＞高脂+力竭游泳。受纳入研究质量和数量的限制，所得结论仍待进一步验证。结论：右旋糖酐、冰水浴、多因素刺激、肾上腺素造模效果更显著。 |
| English Summary: |
| To evaluate the effect of different modeling methods for acute blood stasis syndrome by network meta-analysis and provide an evidence-based basis for the preparation of an animal model with acute blood stasis syndrome in research of traditional Chinese medicine(TCM).Methods:The modeling methods for acute blood stasis syndrome were searched from Databases of China National Knowledge Infrastructure(CNKI)，China Science Periodical Database(CSPD)，and Chinese Citation Database(CCD).The network meta-analysis was carried out by Stata software.Results:A total of 32 pieces of literature and nine modeling schemes were finally included.The best first three probability indexes were ranked as follows：1) whole blood viscosity：1 S-1 shear rate dextran>high fat>hydrocortisone+adrenaline，10 S-1 shear rate ice water bath>adrenaline>high-fat feeding+exhaustive swimming，30 S-1 shear rate multifactor stimulation>dextran>adrenaline，60 S-1 shear rate multifactor stimulation>dextran>adrenaline，150 S-1 shear rate adrenaline>ice water bath>high-fat feeding+exhaustive swimming，200 S-1 shear rate dextran>hydrocortisone+adrenaline>carrageenan+endotoxin; 2) plasma viscosity：dextran>multifactor stimulation>adrenaline; 3)erythrocyte aggregation index：ice water bath>multifactor stimulation>high-fat feeding+exhaustive swimming.Limited by the quality and quantity of the included studies，the conclusions still need to be further verified.Conclusion:dextran，ice water bath，multifactor stimulation，and adrenaline are more effective in modeling. |
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