| 引用本文:黄丽1，王秋月1，张小晋1，范轶斌1，丁鲁1，金珠1，吴焕淦2.陆氏健脾和胃针刺法治疗代谢综合征的随机对照研究[J].世界中医药,2024,(14):. |
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| 陆氏健脾和胃针刺法治疗代谢综合征的随机对照研究 |
| Randomized Controlled Study on the Treatment of Metabolic Syndrome with Lu's Spleen-invigorating and Stomach-harmonizing Acupuncture Method |
| 投稿时间：2023-02-25 |
| DOI：10.3969/j.issn.1673-7202.2024.14.019 |
| 中文关键词: 针刺；代谢综合征；陆氏针灸；流派传承；随机对照试验；经络 辨证；健脾和胃；远期 疗效 |
| English Keywords:Acupuncture Metabolic syndrome Lu's acupuncture and moxibustion School inheritance Randomized controlled trial Meridian and collaterals Syndrome differentiation Invigorating the spleen and harmonizing the stomach Long term Efficacy |
| 基金项目:国家重点基础研究发展计划“973计划”项目（2015CB554501）；国家中医药领军人才“岐黄学者”；上海市卫生健康委员会面上项目（202040002）;上海市浦东新区卫生健康委员会优秀青年医学人才培养项目（PWRq2023-47） |
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| 中文摘要: |
| 目的：观察陆氏健脾和胃针刺法治疗代谢综合征（MetS）的临床疗效。方法：选取2020年3月至2022年3月于上海市第七人民医院就诊的MetS患者90例作为研究对象，按照随机数字表法分为观察组和对照组，每组45例。对照组采用健康宣教及常规药物治疗，观察组在此基础上加用陆氏健脾和胃针刺法。比较2组患者治疗前后体质量、腰围、体质量指数（BMI）、血脂、血糖、血压的变化。结果：意向性治疗（ITT）分析结果显示，2组患者各时间点体质量、腰围及BMI均较治疗前显著降低（P<0.05），且观察组各时间点体质量、腰围及BMI显著低于对照组（P<0.05）；2组患者治疗后血清总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）均较治疗前下降（P<0.05），高密度脂蛋白胆固醇（HDL-C）明显上升（P<0.05），治疗后观察组TC、TG、HDL-C变化幅度较对照组更显著（P<0.05）；2组患者治疗后空腹血糖（FBG）、糖化血红蛋白（HbA1c）及胰岛素抵抗指数（HOMA-IR）均比治疗前降低（P<0.05），治疗后观察组FPG、HbA1c及HOMA-IR值均比对照组降低明显（P<0.05）。2组患者治疗前后血压指标无明显变化（P>0.05），针刺期待值与临床疗效无明显相关性（P>0.05）。结论：陆氏健脾和胃法针刺法能有效降低MetS患者的体质量、腰围、BMI，改善血脂、血糖水平，并且具有良好的远期疗效。 |
| English Summary: |
| To observe the clinical efficacy of Lu's spleen-invigorating and stomach-harmonizing acupuncture method in the treatment of metabolic syndrome(MetS).Methods:Ninety MetS patients who visited the Seventh People's Hospital of Shanghai from March 2020 to March 2022 were enrolled and randomly divided into an observation group and a control group according to a random number table，with 45 patients in each group.The control group received health education and conventional drug treatment，while the observation group additionally received Lu's spleen-invigorating and stomach-harmonizing acupuncture method.Changes in weight，waist circumference，body mass index(BMI)，blood lipids，blood glucose，and blood pressure were compared before and after treatment in both groups.Results:Intent-to-treat(ITT) analysis showed that weight，waist circumference，and BMI significantly decreased at each time point in both groups compared to those before treatment(P<0.05).The weight，waist circumference，and BMI in the observation group were lower than those in the control group at each time point(P<0.05).After treatment，both groups showed significant decreases in serum total cholesterol(TC) and low-density lipoprotein cholesterol(LDL-C)(P<0.05)，and significant increases in high-density lipoprotein cholesterol(HDL-C) compared to those before treatment(P<0.05).The changes in TC，triglycerides(TG)，and HDL-C were more significant in the observation group than in the control group(P<0.05).Fasting blood glucose(FBG)，glycated hemoglobin(HbA1c)，and homeostasis model assessment of insulin resistance(HOMA-IR) decreased significantly in both groups after treatment(P<0.05)，with greater reductions in the observation group than in the control group(P<0.05).There were no significant changes in blood pressure indicators before and after treatment in either group(P>0.05)，and the expectation of acupuncture efficacy was not significantly correlated with clinical outcomes(P>0.05).Conclusion:Lu's spleen-invigorating and stomach-harmonizing acupuncture method can effectively reduce weight，waist circumference，and BMI in MetS patients，improve blood lipid and blood glucose levels，and has good long-term efficacy. |
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